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变异的新冠病毒

Mutated COVID.

作者信息

Dawood A A

机构信息

College of Medicine, University of Mosul, Mosul, Iraq.

出版信息

New Microbes New Infect. 2020 Apr 4;35:100673. doi: 10.1016/j.nmni.2020.100673. eCollection 2020 May.

Abstract

Coronavirus disease 2019 SARS-CoV-2 (COVID-19) is a zoonotic virus causing a variety of severe respiratory diseases. SARS-CoV-2 is closest to SARS-CoV and MERS-CoV in structure. The high prevalence of COVID-19 is a result of a lack of symptoms at onset. Our study aimed to present an overview of the virus in terms of structure, epidemiology, symptoms, treatment and prevention. Whole genome sequences and some viral proteins were investigated to determine gaps and changes in alternation of nucleotides and amino acid sequences. We evaluate 11 complete genome sequences of different coronaviruses using BAST and MAFFT software. We also selected seven types of structural proteins. We conclude that COVID-19 might produce new mutations, specifically in glycoproteins, so caution and complete preparation by health authorities is required.

摘要

2019冠状病毒病(SARS-CoV-2,即COVID-19)是一种人畜共患病毒,可引发多种严重呼吸道疾病。SARS-CoV-2在结构上与SARS-CoV和MERS-CoV最为接近。COVID-19的高流行率是由于发病时缺乏症状所致。我们的研究旨在从结构、流行病学、症状、治疗和预防等方面对该病毒进行概述。对全基因组序列和一些病毒蛋白进行了研究,以确定核苷酸和氨基酸序列交替中的差距和变化。我们使用BAST和MAFFT软件评估了11种不同冠状病毒的完整基因组序列。我们还选择了七种结构蛋白。我们得出结论,COVID-19可能会产生新的突变,特别是在糖蛋白中,因此卫生当局需要谨慎并做好充分准备。

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