Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Department of Chemistry, Alwajh College, University of Tabuk, Tabuk 47512, Saudi Arabia.
Molecules. 2022 Nov 15;27(22):7893. doi: 10.3390/molecules27227893.
Herbal products are a major source of herbal medicines and other medicines. Essential oils have shown various pharmacological activities, such as antiviral activity, and therefore are proposed to have potential activity against SARS-CoV-2. Due to their lipophilicity, essential oils can easily penetrate the viral membrane and cause the viral membrane to rupture. In addition, crude essential oils usually have many active constituents that can act on different parts of the virus including its cell entry, translation, transcription, and assembly. They have further beneficial pharmacological effects on the host's respiratory system, including anti-inflammatory, immune regulation, bronchiectasis, and mucolytics. This review reported potential essential oils which could be promising drugs for COVID-19 eradication. Essential oils have many advantages because they are promising volatile antiviral molecules, making them potential drug targets for the prevention and treatment of COVID-19, whether used alone or in combination with other chemotherapeutic drugs. The aim of the current review is to shed light on the potential essential oils against enveloped viruses and their proposed activity against SARS-CoV-2 which is also an enveloped virus. The objectives were to present all data reflecting the promising activities of diverse essential oils against enveloped viruses and how they could contribute to the eradication of COVID disease, especially in indoor places. The data collected for the current review were obtained through the SciFinder database, Google scholar, PubMed, and Mendeley database. The data of the current review focused on the most common essential oils which are available in the pharmaceutical market and showed noticeable activities against enveloped viruses such as HSV and influenza.
草药产品是草药和其他药物的主要来源。精油具有多种药理活性，如抗病毒活性，因此被认为对 SARS-CoV-2 具有潜在的活性。由于其亲脂性，精油可以轻易穿透病毒膜并导致病毒膜破裂。此外，粗制精油通常含有许多可以作用于病毒不同部位的活性成分，包括其细胞进入、翻译、转录和组装。它们对宿主呼吸系统还有进一步有益的药理作用，包括抗炎、免疫调节、支气管扩张和黏液溶解。本综述报道了一些有潜力的精油，它们可能是消灭 COVID-19 的有前途的药物。精油具有许多优点，因为它们是有前途的挥发性抗病毒分子，使它们成为预防和治疗 COVID-19 的潜在药物靶点，无论是单独使用还是与其他化疗药物联合使用。本综述的目的是阐明针对包膜病毒的潜在精油及其对 SARS-CoV-2 的拟议活性，SARS-CoV-2 也是一种包膜病毒。目的是呈现所有反映各种精油对包膜病毒的有前途活性的数据，以及它们如何有助于消灭 COVID 疾病，特别是在室内场所。本综述中收集的数据是通过 SciFinder 数据库、Google Scholar、PubMed 和 Mendeley 数据库获得的。本综述的数据集中在最常见的精油上，这些精油在制药市场上有供应，并对 HSV 和流感等包膜病毒表现出明显的活性。
