用于帕金森病患者的个体生活质量测量指标——患者生成指数的验证
Validation of an Individualized Measure of Quality of Life, Patient Generated Index, for Use with People with Parkinson's Disease.
作者信息
Kuspinar Ayse, Mate Kedar K V, Lafontaine Anne-Louise, Mayo Nancy
机构信息
School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.
Center for Outcomes Research and Evaluation, McGill University Health Centre-Research Institute, Montreal, QC, Canada.
出版信息
Neurol Res Int. 2020 Mar 30;2020:6916135. doi: 10.1155/2020/6916135. eCollection 2020.
METHODS
Patients with PD completed the PGI and various standard patient-reported outcome (PRO) measures. The PGI and standard PRO measures were compared at the total score, domain, and item levels. Pearson's correlations and independent -tests were used, as well as positive and negative predictive values.
RESULTS
The sample ( = 76) had a mean age of 69 (standard deviation 9) and were predominantly men (59%). The PGI was moderately correlated ( = -0.35) with the standardized disease-specific QOL measure Parkinson's Disease Questionnaire (PDQ-8). Within one severity rating, agreement between the PGI and different standard outcome measures ranged from 85 to 100% for walking, 69 to 100% for fatigue, 38 to 75% for depression, and 20 to 80% for memory/concentration.
CONCLUSION
This study demonstrates that nominated areas of QOL on the PGI provide comparable results to standard PRO measures, and provides evidence in support of the validity of this individualized measure in PD.
方法
帕金森病患者完成了总体印象量表（PGI）及各种标准的患者报告结局（PRO）测量。在总分、领域和条目水平上对PGI和标准PRO测量进行比较。使用了Pearson相关性分析、独立样本t检验以及阳性和阴性预测值。
结果
样本（n = 76）的平均年龄为69岁（标准差9），主要为男性（59%）。PGI与标准化的疾病特异性生活质量测量工具帕金森病问卷（PDQ - 8）呈中度相关（r = -0.35）。在一个严重程度等级内，PGI与不同标准结局测量在步行方面的一致性为85%至100%，疲劳方面为69%至100%，抑郁方面为38%至75%，记忆/注意力方面为20%至80%。
结论
本研究表明，PGI上指定的生活质量领域与标准PRO测量结果具有可比性，并为该个体化测量在帕金森病中的有效性提供了支持证据。
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