Nutrition and Metabolic Disease Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Nutrition Department, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Nutr J. 2020 Apr 15;19(1):33. doi: 10.1186/s12937-020-00548-6.
This study aimed to summarize earlier studies on the effects of RS consumption on the serum levels of inflammatory biomarkers.
A comprehensive search was done in the electronic databases that published from 1988 up to May 2019. Two reviewers independently performed screening, data extraction, and risk-of-bias assessment. We used from the effect size, as estimated by the mean difference to perform the fixed method meta-analysis.
Overall, 13 studies with 14 effect sizes met the inclusion criteria and were included in the final analysis. Sample size of these studies ranged from 15 to 75 and intervention duration ranged from 4 to 14 weeks. Meta-analysis revealed that higher consumption of resistant starch caused a significant reduction in the interleukin 6 (weighted mean difference = - 1.11 pg/mL; 95% CI: - 1.72, - 0.5 pg/mL; P = < 0.001) and tumor necrosis factor alpha (weighted mean difference = - 2.19 pg/mL; 95% CI: - 3.49, - 0.9 pg/mL; P = 0.001) levels. However, no significant changes were found in C-reactive protein concentration (weighted mean difference = - 0.21 mg/L; 95% CI: - 1.06, 0.63 mg/L; P = 0.61). Moreover, the changes in interleukin 6 concentration was dependent on study quality and intervention duration.
The current meta-analysis indicated that RS intake can improve some inflammatory biomarkers. More research, with a large sample sizes and accurate design is recommended.
本研究旨在总结先前关于抗性淀粉（RS）摄入对血清炎症生物标志物水平影响的研究。
对 1988 年至 2019 年 5 月期间发表的电子数据库进行全面检索。两名审查员独立进行筛选、数据提取和偏倚风险评估。我们使用均数差作为效应量进行固定效应荟萃分析。
共有 13 项研究符合纳入标准，共纳入 14 个效应量。这些研究的样本量范围为 15 至 75，干预时间范围为 4 至 14 周。荟萃分析显示，较高的抗性淀粉摄入量可显著降低白细胞介素 6（加权均数差=-1.11pg/mL；95%置信区间：-1.72，-0.5pg/mL；P<0.001）和肿瘤坏死因子-α（加权均数差=-2.19pg/mL；95%置信区间：-3.49，-0.9pg/mL；P=0.001）水平。然而，C-反应蛋白浓度（加权均数差=-0.21mg/L；95%置信区间：-1.06，0.63mg/L；P=0.61）无显著变化。此外，白细胞介素 6 浓度的变化取决于研究质量和干预时间。
目前的荟萃分析表明，RS 摄入可以改善一些炎症生物标志物。建议进行更多具有大样本量和准确设计的研究。
