• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

全数字化工作流程用于制造定制化直接金属激光烧结（DMLS）下颌植入物：一例报告。

Full-Digital Workflow for Fabricating a Custom-Made Direct Metal Laser Sintering (DMLS) Mandibular Implant: A Case Report.

机构信息

Department of Maxillofacial Surgery, IRCCS Istituto Ortopedico Galeazzi, Via Galeazzi 4, 20161 Milan, Italy.

Department of Medicine and Surgery, Dental School, University of Varese, Via Piatti 10, 21100 Varese, Italy.

出版信息

Int J Environ Res Public Health. 2020 Apr 14;17(8):2693. doi: 10.3390/ijerph17082693.

DOI:10.3390/ijerph17082693
PMID:32295196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7215385/
Abstract

Direct Laser Metal Sintering (DLMS) is an additive manufacturing (AM) technique that is capable of manufacturing metal parts according to a three-dimensional (3D) design made using computer-assisted-design (CAD) software, thanks to a powerful laser beam that melts selectively micro-powder layers, one on top of the other, until the desired object is generated. With DMLS, it is now possible to fabricate custom-made titanium implants for oral and maxillofacial applications. We present the case of a 67-year-old woman diagnosed with a squamous cell carcinoma of the mandible. The patient underwent subtotal mandibular resection; conventional reconstruction procedures failed to rehabilitate the function of the mandible. A prosthesis replacing the resected mandible was designed and fabricated using a digital workflow. The extensive bone defect was rehabilitated with a prosthesis replacing the mandibular bone and supporting a morse-taper dental prosthesis. The masticatory function was reestablished.

摘要

直接激光金属烧结（DLMS）是一种增材制造（AM）技术，能够根据使用计算机辅助设计（CAD）软件制作的三维（3D）设计制造金属部件，这要归功于强大的激光束，它可以有选择地熔化微粉末层，一层叠在另一层上面，直到生成所需的物体。通过 DMLS，现在可以为口腔颌面应用制造定制的钛植入物。我们介绍了一位 67 岁女性的病例，她被诊断患有下颌鳞状细胞癌。患者接受了下颌次全切除术；常规重建程序未能恢复下颌的功能。使用数字化工作流程设计并制造了替代切除下颌骨的假体。使用替代下颌骨并支撑 Morse-taper 牙科假体的假体来修复广泛的骨缺损。重建了咀嚼功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/73a7cd5e4e0d/ijerph-17-02693-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/40190f0600ac/ijerph-17-02693-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/64b0948b7db6/ijerph-17-02693-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/b306e5c597ae/ijerph-17-02693-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/aa1fd41f7f6d/ijerph-17-02693-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/8cd69b0a3db4/ijerph-17-02693-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/c7c9735ff533/ijerph-17-02693-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/a0497f63b3ad/ijerph-17-02693-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/6773e68ce62b/ijerph-17-02693-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/0350489557c7/ijerph-17-02693-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/d9a8b8e07118/ijerph-17-02693-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/e90521f3a5a9/ijerph-17-02693-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/a96250eeab2e/ijerph-17-02693-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/f0ab0705fe23/ijerph-17-02693-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/a84968881c7e/ijerph-17-02693-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/e27672944ef8/ijerph-17-02693-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/5fb368f215a3/ijerph-17-02693-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/73a7cd5e4e0d/ijerph-17-02693-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/40190f0600ac/ijerph-17-02693-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/64b0948b7db6/ijerph-17-02693-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/b306e5c597ae/ijerph-17-02693-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/aa1fd41f7f6d/ijerph-17-02693-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/8cd69b0a3db4/ijerph-17-02693-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/c7c9735ff533/ijerph-17-02693-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/a0497f63b3ad/ijerph-17-02693-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/6773e68ce62b/ijerph-17-02693-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/0350489557c7/ijerph-17-02693-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/d9a8b8e07118/ijerph-17-02693-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/e90521f3a5a9/ijerph-17-02693-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/a96250eeab2e/ijerph-17-02693-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/f0ab0705fe23/ijerph-17-02693-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/a84968881c7e/ijerph-17-02693-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/e27672944ef8/ijerph-17-02693-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/5fb368f215a3/ijerph-17-02693-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9d84/7215385/73a7cd5e4e0d/ijerph-17-02693-g017.jpg

相似文献

1
Full-Digital Workflow for Fabricating a Custom-Made Direct Metal Laser Sintering (DMLS) Mandibular Implant: A Case Report.全数字化工作流程用于制造定制化直接金属激光烧结（DMLS）下颌植入物：一例报告。
Int J Environ Res Public Health. 2020 Apr 14;17(8):2693. doi: 10.3390/ijerph17082693.
2
An alternative digital workflow for fabricating a mandibular implant-supported complete fixed dental prosthesis with limited restorative space: A clinical report.一种用于在有限修复空间内制作下颌种植体支持的全固定义齿的替代数字化工作流程：一份临床报告。
J Prosthet Dent. 2018 Jul;120(1):1-4. doi: 10.1016/j.prosdent.2017.11.023. Epub 2018 Mar 23.
3
Contour Restoration of Over-Resected Mandibular Angle and Lower Border by Reduction Mandibuloplasty Using Three-Dimensional Planning and Computer-Aided Design and Manufacturing Custom-Made Titanium Implants.采用三维规划及计算机辅助设计与制造定制钛植入物的下颌骨缩小成形术对过度切除的下颌角及下颌下缘进行轮廓修复
J Craniofac Surg. 2018 Jun;29(4):e340-e343. doi: 10.1097/SCS.0000000000004283.
4
Clinical and volumetric outcomes after vertical ridge augmentation using computer-aided-design/computer-aided manufacturing (CAD/CAM) customized titanium meshes: a pilot study.采用计算机辅助设计/计算机辅助制造（CAD/CAM）定制钛网进行垂直骨增量的临床和容量学效果：一项初步研究。
BMC Oral Health. 2020 Aug 5;20(1):219. doi: 10.1186/s12903-020-01205-4.
5
A Technique for Restoring Severely Resorbed Edentulous Mandible with a Computer-aided Design and Computer-aided Manufacturing Surgical Guide and an Implant-supported Fixed Dental Prosthesis in Two Days.一种利用计算机辅助设计与计算机辅助制造手术导板及种植体支持的固定义齿在两天内修复严重吸收的无牙下颌骨的技术。
J Contemp Dent Pract. 2019 Apr 1;20(4):524-528.
6
Mandibular Reconstruction Using a Customized Three-Dimensional Titanium Implant Applied on the Lingual Surface of the Mandible.使用定制三维钛植入物应用于下颌骨舌面进行下颌骨重建。
J Craniofac Surg. 2018 Mar;29(2):415-419. doi: 10.1097/SCS.0000000000004119.
7
Simultaneous Computer-Aided Design/Computer-Aided Manufacture Bimaxillary Orthognathic Surgery and Mandibular Reconstruction Using Selective-Laser Sintered Titanium Implant.使用选择性激光烧结钛植入物的同步计算机辅助设计/计算机辅助制造双颌正颌手术及下颌骨重建
J Craniofac Surg. 2016 Oct;27(7):1810-1814. doi: 10.1097/SCS.0000000000003039.
8
Immediate loading of mandibular overdentures supported by one-piece, direct metal laser sintering mini-implants: a short-term prospective clinical study.由一体式直接金属激光烧结微型种植体支持的下颌覆盖义齿即刻负重：一项短期前瞻性临床研究。
J Periodontol. 2015 Feb;86(2):192-200. doi: 10.1902/jop.2014.140343. Epub 2014 Oct 2.
9
Immediate, non-submerged, root-analogue direct laser metal sintering (DLMS) implants: a 1-year prospective study on 15 patients.即刻、非浸没式、牙根模拟直接激光金属烧结（DLMS）种植体：对15例患者的1年前瞻性研究。
Lasers Med Sci. 2014 Jul;29(4):1321-8. doi: 10.1007/s10103-013-1299-0. Epub 2013 Mar 15.
10
[Application of computer aided design-computer aided manufacture technique in mandible defect reconstruction with individual titanium prosthesis].计算机辅助设计-计算机辅助制造技术在个体化钛假体下颌骨缺损重建中的应用
Zhonghua Kou Qiang Yi Xue Za Zhi. 2011 Jul;46(7):422-4.

引用本文的文献

1
Innovative 3D printing technologies and advanced materials revolutionizing orthopedic surgery: current applications and future directions.创新的3D打印技术和先进材料正在彻底改变骨科手术：当前应用与未来方向。
Front Bioeng Biotechnol. 2025 Feb 11;13:1542179. doi: 10.3389/fbioe.2025.1542179. eCollection 2025.
2
Analysis of the Effectiveness of 3D Printed Patient-Specific Implants for Reconstruction of Maxillary Defect Secondary to Mucormycosis.3D打印定制植入物用于毛霉菌病继发上颌骨缺损重建的有效性分析
J Maxillofac Oral Surg. 2023 Sep;22(3):728-733. doi: 10.1007/s12663-023-01922-7. Epub 2023 Jun 20.
3

本文引用的文献

1
Double-Barrel Fibula Flap Versus Vascularized Iliac Crest Flap for Mandibular Reconstruction.双筒腓骨瓣与带血管蒂髂嵴瓣在下颌骨重建中的应用比较
J Oral Maxillofac Surg. 2020 May;78(5):844-850. doi: 10.1016/j.joms.2020.01.003. Epub 2020 Jan 13.
2
Experimental Biointegration of a Titanium Implant in Delayed Mandibular Reconstruction.钛植入物在延迟性下颌骨重建中的实验性生物整合
J Pers Med. 2020 Feb 3;10(1):6. doi: 10.3390/jpm10010006.
3
The Effect of Different Antibiotic Regimens on Bacterial Resistance: A Systematic Review.不同抗生素治疗方案对细菌耐药性的影响：一项系统评价
Additively manufactured metallic biomaterials.
增材制造金属生物材料
Bioact Mater. 2021 Dec 30;15:214-249. doi: 10.1016/j.bioactmat.2021.12.027. eCollection 2022 Sep.
4
Computed Tomography as a Characterization Tool for Engineered Scaffolds with Biomedical Applications.计算机断层扫描作为具有生物医学应用的工程支架的表征工具。
Materials (Basel). 2021 Nov 10;14(22):6763. doi: 10.3390/ma14226763.
Antibiotics (Basel). 2020 Jan 8;9(1):22. doi: 10.3390/antibiotics9010022.
4
A Literature Review of Metagenomics and Culturomics of the Peri-implant Microbiome: Current Evidence and Future Perspectives.种植体周围微生物群的宏基因组学和培养组学文献综述：当前证据与未来展望
Materials (Basel). 2019 Sep 17;12(18):3010. doi: 10.3390/ma12183010.
5
Current state of the art in the use of augmented reality in dentistry: a systematic review of the literature.当前口腔医学中增强现实技术的应用现状：文献系统评价。
BMC Oral Health. 2019 Jul 8;19(1):135. doi: 10.1186/s12903-019-0808-3.
6
3D printed titanium prosthesis reconstruction following subtotal maxillectomy for myoepithelial carcinoma - a case report.3D 打印钛假体重建用于颌骨次全切除术的肌上皮癌-病例报告。
J Stomatol Oral Maxillofac Surg. 2020 Apr;121(2):175-178. doi: 10.1016/j.jormas.2019.03.013. Epub 2019 Mar 25.
7
Evaluation of virtual surgical plan applicability in 3D simulation-guided two-jaw surgery.三维模拟引导下双颌手术中虚拟手术计划适用性的评估。
J Craniomaxillofac Surg. 2019 Jun;47(6):860-866. doi: 10.1016/j.jcms.2019.03.005. Epub 2019 Mar 13.
8
Computer-assisted surgery for reconstruction of complex mandibular defects using osteomyocutaneous microvascular fibular free flaps: Use of a skin paddle-outlining guide for soft-tissue reconstruction. A technical report.计算机辅助手术在应用骨肌皮瓣游离腓骨重建下颌骨复杂缺损中的应用：皮瓣轮廓导板在软组织重建中的应用。技术报告。
J Craniomaxillofac Surg. 2019 Feb;47(2):293-299. doi: 10.1016/j.jcms.2018.11.018. Epub 2018 Nov 28.
9
In house virtual surgery and 3D complex head and neck reconstruction.在院内心血管手术和 3D 复杂头颈重建。
J Otolaryngol Head Neck Surg. 2018 Dec 12;47(1):75. doi: 10.1186/s40463-018-0320-9.
10
Accuracy of CAD/CAM mandibular reconstruction: A three-dimensional, fully virtual outcome evaluation method.CAD/CAM 下颌骨重建的准确性：一种三维、全虚拟的结果评估方法。
J Craniomaxillofac Surg. 2018 Jul;46(7):1121-1125. doi: 10.1016/j.jcms.2018.05.010. Epub 2018 May 10.