Kang Seung-Gul, Lee Jong Hun, Lee Kwanghun, Kim Hee-Cheol, Seo Wan Seok, Won Seunghee
Department of Psychiatry, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
Department of Psychiatry, College of Medicine, Daegu Catholic University, Daegu, Republic of Korea.
Psychiatry Investig. 2020 May;17(5):417-423. doi: 10.30773/pi.2020.0012. Epub 2020 Apr 17.
Since the risk of suicide cannot be predicted by clinical symptoms alone, and suicide is known to have a genetic component, the discovery of genetic markers that can predict the lethality of suicide attempts is a clinically important topic. There have been many studies aiming to determine whether the rs6265 polymorphism of the BDNF gene is associated with suicidality; however, the results have been mixed, and there have been few studies investigating the relationship between this polymorphism and suicide attempt lethality.
We assessed suicide lethality in 258 individuals who had attempted suicide using the relative risk ratio (RRR) scale and by genotyping the rs6265 polymorphism of the BDNF gene.
The RRR score for suicide attempts was higher in subjects with Met/Val and Val/Val genotypes than in that with a Met/Met genotype (p=0.015). The RRR score for suicide attempts was also higher in Val allele carriers (Met/Val+Val/Val) than in Met/Met homozygotes (p=0.006).
This study demonstrates the possibility that the rs6265 polymorphism of the BDNF gene could be used as a genetic marker to predict the lethality of suicide attempts, but more replication studies are needed for the application of this result in clinical practice.
由于自杀风险不能仅通过临床症状来预测，且已知自杀具有遗传因素，因此发现能够预测自杀未遂致死性的遗传标记是一个具有临床重要性的课题。已有许多研究旨在确定脑源性神经营养因子（BDNF）基因的rs6265多态性是否与自杀行为有关；然而，结果不一，且很少有研究调查这种多态性与自杀未遂致死性之间的关系。
我们使用相对风险比（RRR）量表并通过对BDNF基因的rs6265多态性进行基因分型，评估了258名自杀未遂者的自杀致死性。
携带Met/Val和Val/Val基因型的自杀未遂者的RRR评分高于携带Met/Met基因型的自杀未遂者（p = 0.015）。Val等位基因携带者（Met/Val + Val/Val）的自杀未遂RRR评分也高于Met/Met纯合子（p = 0.006）。
本研究表明BDNF基因的rs6265多态性有可能作为预测自杀未遂致死性的遗传标记，但要将这一结果应用于临床实践还需要更多的重复研究。
