Xia Ming, Liu Di, Liu Yu, Liu Hong
Department of Nephrology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Kidney Disease and Blood Purification, Changsha, China.
Front Pharmacol. 2020 Mar 31;11:380. doi: 10.3389/fphar.2020.00380. eCollection 2020.
Artemisinin (ARS) and its derivatives (ARSs) are recommended as the first-line antimalarial drugs for the treatment of malaria. Besides antimalarial function, its potent anti-inflammatory and immunoregulatory properties, as well as the ability to regulate oxidative stress have brought them to a prominent position. As researchers around the world are continually exploring the unknown biological activities of ARS derivatives, experimental studies have shown much progress in renal therapy. This review aims to give a brief overview of the current research on ARSs applications for kidney treatment with the evaluation of therapeutic properties and potential molecular mechanisms.
青蒿素（ARS）及其衍生物（ARSs）被推荐作为治疗疟疾的一线抗疟药物。除了抗疟功能外，其强大的抗炎和免疫调节特性以及调节氧化应激的能力使其备受瞩目。随着世界各地的研究人员不断探索青蒿素衍生物未知的生物活性，实验研究在肾脏治疗方面已取得了很大进展。本综述旨在简要概述目前关于青蒿素类药物在肾脏治疗中的应用研究，同时评估其治疗特性和潜在的分子机制。
