Single-Cell RNA Sequencing Reveals Cell-Type-Specific Mechanisms of Neurological Diseases.
作者信息
Luo Zhen-Ge, Peng Jian, Li Ting
机构信息
School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China.
Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
出版信息
Neurosci Bull. 2020 Jul;36(7):821-824. doi: 10.1007/s12264-020-00496-5. Epub 2020 Apr 15.
Abstract
摘要
相似文献
1
Single-Cell RNA Sequencing Reveals Cell-Type-Specific Mechanisms of Neurological Diseases.
Neurosci Bull. 2020 Jul;36(7):821-824. doi: 10.1007/s12264-020-00496-5. Epub 2020 Apr 15.
2
Integrated sequencing of exome and mRNA of large-sized single cells.大片段单细胞外显子组和 mRNA 整合测序。
Sci Rep. 2018 Jan 10;8(1):384. doi: 10.1038/s41598-017-18730-y.
3
Single-cell RNA sequencing reveals spatial heterogeneity and immune evasion of circulating tumor cells.单细胞RNA测序揭示循环肿瘤细胞的空间异质性和免疫逃逸
Cancer Biol Med. 2021 Nov 24;18(4):934-6. doi: 10.20892/j.issn.2095-3941.2021.0466.
4
Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets.人胰岛的单细胞RNA测序与分析
J Vis Exp. 2019 Jul 18(149). doi: 10.3791/59866.
5
Utility of Whole Exome Sequencing for Genetic Diagnosis of Previously Undiagnosed Pediatric Neurology Patients.全外显子测序在既往未确诊的儿科神经疾病患者基因诊断中的应用
J Child Neurol. 2016 Dec;31(14):1534-1539. doi: 10.1177/0883073816664836. Epub 2016 Aug 29.
6
A comparative analysis of single cell small RNA sequencing data reveals heterogeneous isomiR expression and regulation.单细胞小RNA测序数据的比较分析揭示了异质性的异构体miRNA表达与调控。
Sci Rep. 2022 Feb 18;12(1):2834. doi: 10.1038/s41598-022-06876-3.
7
Rapid exome sequencing in PICU patients with new-onset metabolic or neurological disorders.在新发代谢或神经障碍的 PICU 患者中进行快速外显子组测序。
Pediatr Res. 2020 Nov;88(5):761-768. doi: 10.1038/s41390-020-0858-x. Epub 2020 Mar 27.
8
Characterization of X chromosome inactivation using integrated analysis of whole-exome and mRNA sequencing.利用全外显子组和mRNA测序的综合分析对X染色体失活进行表征
PLoS One. 2014 Dec 12;9(12):e113036. doi: 10.1371/journal.pone.0113036. eCollection 2014.
9
The Three Rs of Single-Cell RNA Sequencing: Reuse, Refine, and Resource.单细胞 RNA 测序的“3R”原则：再利用、优化和资源。
J Invest Dermatol. 2021 Jul;141(7):1627-1629. doi: 10.1016/j.jid.2021.01.002.
10
The combination of whole-exome sequencing and copy number variation sequencing enables the diagnosis of rare neurological disorders.全外显子测序和拷贝数变异测序的结合使得罕见神经疾病的诊断成为可能。
Clin Genet. 2019 Aug;96(2):140-150. doi: 10.1111/cge.13548. Epub 2019 Apr 22.
引用本文的文献
1
Identification of cell specific biomarkers for intellectual disability via single cell RNA sequencing and transcriptomic bioinformatics approaches.通过单细胞RNA测序和转录组生物信息学方法鉴定智力残疾的细胞特异性生物标志物。
Sci Rep. 2025 May 21;15(1):17609. doi: 10.1038/s41598-025-85162-4.
2
Cryptic mitochondrial DNA mutations coincide with mid-late life and are pathophysiologically informative in single cells across tissues and species.隐匿性线粒体DNA突变与中老年期相符，且在跨组织和物种的单细胞中具有病理生理学信息。
Nat Commun. 2025 Mar 6;16(1):2250. doi: 10.1038/s41467-025-57286-8.
3
Multimodal Nature of the Single-cell Primate Brain Atlas: Morphology, Transcriptome, Electrophysiology, and Connectivity.单细胞灵长类大脑图谱的多模态性质：形态、转录组、电生理学和连接性。
Neurosci Bull. 2024 Apr;40(4):517-532. doi: 10.1007/s12264-023-01160-4. Epub 2024 Jan 9.
4
Progress in Modeling Neural Tube Development and Defects by Organoid Reconstruction.通过类器官重建对神经管发育和缺陷进行建模的进展
Neurosci Bull. 2022 Nov;38(11):1409-1419. doi: 10.1007/s12264-022-00896-9. Epub 2022 Jun 26.
本文引用的文献
1
A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation.阿尔茨海默病患者内嗅皮层的单细胞图谱揭示了细胞类型特异性基因表达调控。
Nat Neurosci. 2019 Dec;22(12):2087-2097. doi: 10.1038/s41593-019-0539-4.
2
Towards the Framework of Understanding Autism Spectrum Disorders.迈向理解自闭症谱系障碍的框架。
Neurosci Bull. 2019 Nov 9;35(6):1110-2. doi: 10.1007/s12264-019-00443-z.
3
Single-cell genomics identifies cell type-specific molecular changes in autism.单细胞基因组学鉴定自闭症中细胞类型特异性的分子变化。
Science. 2019 May 17;364(6441):685-689. doi: 10.1126/science.aav8130.
4
Single-cell transcriptomic analysis of Alzheimer's disease.阿尔茨海默病的单细胞转录组分析。
Nature. 2019 Jun;570(7761):332-337. doi: 10.1038/s41586-019-1195-2. Epub 2019 May 1.
5
Clinical Research on Alzheimer's Disease: Progress and Perspectives.阿尔茨海默病的临床研究：进展与展望。
Neurosci Bull. 2018 Dec;34(6):1111-1118. doi: 10.1007/s12264-018-0249-z. Epub 2018 Jun 28.
6
Religious Orders Study and Rush Memory and Aging Project.宗教秩序研究和冲刺记忆与衰老项目。
J Alzheimers Dis. 2018;64(s1):S161-S189. doi: 10.3233/JAD-179939.
7
Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain.人类成年大脑中转录和表观遗传状态的综合单细胞分析。
Nat Biotechnol. 2018 Jan;36(1):70-80. doi: 10.1038/nbt.4038. Epub 2017 Dec 11.
8
An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options.自闭症谱系障碍、异质性及治疗选择概述
Neurosci Bull. 2017 Apr;33(2):183-193. doi: 10.1007/s12264-017-0100-y. Epub 2017 Feb 17.
9
Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain.人类大脑单细胞 RNA 测序揭示的神经元亚型和多样性。
Science. 2016 Jun 24;352(6293):1586-90. doi: 10.1126/science.aaf1204.
10
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.对 74046 人的荟萃分析确定了 11 个阿尔茨海默病的新易感性位点。
Nat Genet. 2013 Dec;45(12):1452-8. doi: 10.1038/ng.2802. Epub 2013 Oct 27.
Zotero 插件