一种用于检测遗传毒性化合物的信号检测法：在接受化疗的癌症患者尿液及处理细胞毒性药物的护士尿液中的应用。

A signal assay for the detection of genotoxic compounds: application on the urines of cancer patients on chemotherapy and of nurses handling cytotoxic drugs.

Burgaz S, Ozdamar Y N, Karakaya A E

Department of Toxicology, Faculty of Pharmacy, Gazi University, Hipodrom, Ankara, Turkey.

Hum Toxicol. 1988 Nov;7(6):557-60. doi: 10.1177/096032718800700607.

Abstract

The excretion of thioethers was determined in the urine of nurses handling cytotoxic drugs (n = 10) and cancer patients under chemotherapy (n = 32). 2. An occupational non-exposed group served as control (n = 28). 3. We found no association between the handling of cytotoxic drugs and occupational exposure of nurses. Cancer patients under chemotherapy showed abnormally high values of thioethers, while urinary thioether concentration was, consistently, rather low in some individuals under intensive chemotherapy. 4. We conclude that periodical urinary thioether determinations should be made available to hospital staff as well as cancer patients to minimize the risks of the cytotoxic drugs.

摘要

测定了接触细胞毒性药物的护士（n = 10）和接受化疗的癌症患者（n = 32）尿液中的硫醚排泄情况。2. 一个职业未接触组作为对照（n = 28）。3. 我们发现细胞毒性药物的处理与护士的职业暴露之间没有关联。接受化疗的癌症患者硫醚值异常高，而在强化化疗的一些个体中，尿硫醚浓度一直相当低。4. 我们得出结论，应为医院工作人员以及癌症患者进行定期尿硫醚测定，以将细胞毒性药物的风险降至最低。