Australian Institute for Musculoskeletal Science (AIMSS), The University of Melbourne and Western Health, St. Albans, Australia.
Department of Medicine-Western Health, University of Melbourne, St. Albans, Australia.
J Gerontol A Biol Sci Med Sci. 2020 Oct 15;75(11):2031-2036. doi: 10.1093/gerona/glaa093.
Long-term caloric restriction (CR) has been shown to be beneficial to various tissues and organs. In contrast, CR exerts differential effects on bone, which could be due in part to the nature of the protein regime utilized. Male Sprague Dawley rats (8-month-old) were subjected for 12 months to 40% CR in macronutrients and compared with rats fed ad libitum for the same period. Casein- and soy-fed groups were compared. There was a significant decrease in bone quality in both CR groups, which was independent of the source of protein in the diet. In contrast, the group fed soy protein ad libitum showed better bone quality and higher levels of bone formation compared with casein-fed animals. Notably, bone marrow adipocytes were not mobilized upon CR as demonstrated by an absence of change in adipocyte number and tissue expression of leptin. This study demonstrates that the negative effect of CR on bone quality could not be prevented by the most common protein regimes.
长期热量限制（CR）已被证明对各种组织和器官有益。相比之下，CR 对骨骼的影响存在差异，这部分原因可能是由于所使用的蛋白质方案的性质不同。雄性 Sprague Dawley 大鼠（8 个月大）接受了 12 个月的 40%热量限制，与同期自由进食的大鼠进行了比较。比较了酪蛋白和大豆喂养组。两组 CR 大鼠的骨质量均显著下降，这与饮食中蛋白质的来源无关。相比之下，与酪蛋白喂养的动物相比，自由进食大豆蛋白的大鼠显示出更好的骨质量和更高水平的骨形成。值得注意的是，正如脂肪细胞数量和瘦素组织表达无变化所证明的那样，CR 并未动员骨髓脂肪细胞。本研究表明，最常见的蛋白质方案并不能防止 CR 对骨质量的负面影响。
