Molecular Disease Mechanisms Group, Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Eco-Systems Biology group, Luxembourg Center for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Trends Microbiol. 2020 May;28(5):401-423. doi: 10.1016/j.tim.2020.01.001. Epub 2020 Feb 13.
Mounting evidence from metagenomic analyses suggests that a state of pathological microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer. Several bacterial taxa have been identified of which representative isolate cultures interact with human cancer cells in vitro and trigger disease pathways in animal models. However, how the complex interrelationships in dysbiotic communities may be involved in cancer pathogenesis remains a crucial question. Here, we provide a survey of current knowledge of the gut microbiome in colorectal cancer. Moving beyond observational studies, we outline new experimental approaches for gaining ecosystem-level mechanistic understanding of the gut microbiome's role in cancer pathogenesis.
越来越多的元基因组分析证据表明，病理性微生物失衡或失调状态在结直肠癌患者的肠道中很普遍。已经鉴定出了几种细菌分类群，其中代表性的分离培养物在体外与人癌细胞相互作用，并在动物模型中引发疾病途径。然而，失调群落中的复杂相互关系如何可能参与癌症的发病机制仍然是一个关键问题。在这里，我们提供了结直肠癌肠道微生物组的最新知识概述。超越观察性研究，我们概述了新的实验方法，以获得对肠道微生物组在癌症发病机制中的作用的生态系统水平的机制理解。
