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将肿瘤基因组学纳入结直肠癌微生物组研究。

Integrating tumor genomics into studies of the microbiome in colorectal cancer.

机构信息

a Department of Biology , Loyola University Chicago , Chicago , IL , USA.

b Department of Genetics, Cell Biology, and Development , University of Minnesota , Minneapolis , MN , USA.

出版信息

Gut Microbes. 2019;10(4):547-552. doi: 10.1080/19490976.2018.1549421. Epub 2018 Dec 17.

DOI:10.1080/19490976.2018.1549421
PMID:30556775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6748619/
Abstract

Although the gut microbiome has been linked to colorectal cancer (CRC) development, associations of microbial taxa with CRC status are often inconsistent across studies. We have recently shown that tumor genomics, a factor that is rarely incorporated in analyses of the CRC microbiome, has a strong effect on the composition of the microbiota. Here, we discuss these results in the wider context of studies characterizing interaction between host genetics and the microbiome, and describe the implications of our findings for understanding the role of the microbiome in CRC.

摘要

虽然肠道微生物群与结直肠癌 (CRC) 的发展有关，但微生物类群与 CRC 状态的关联在不同的研究中往往不一致。我们最近表明，肿瘤基因组学是很少纳入 CRC 微生物组分析的一个因素，对微生物群落的组成有很强的影响。在这里，我们在更广泛的范围内讨论这些结果，这些研究描述了宿主遗传学和微生物组之间相互作用，并描述了我们的发现对理解微生物组在 CRC 中的作用的意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1660/6748619/1614be605097/kgmi-10-04-1549421-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1660/6748619/08f785bdc7f3/kgmi-10-04-1549421-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1660/6748619/1614be605097/kgmi-10-04-1549421-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1660/6748619/08f785bdc7f3/kgmi-10-04-1549421-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1660/6748619/1614be605097/kgmi-10-04-1549421-g002.jpg

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本文引用的文献

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2
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Curr Opin Microbiol. 2018 Aug;44:9-19. doi: 10.1016/j.mib.2018.05.003. Epub 2018 Jun 14.
3
Leveraging Existing 16S rRNA Gene Surveys To Identify Reproducible Biomarkers in Individuals with Colorectal Tumors.
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J Oral Microbiol. 2022 Jul 15;14(1):2098644. doi: 10.1080/20002297.2022.2098644. eCollection 2022.
4
The Interaction Between the Microbiome and Tumors.微生物组与肿瘤的相互作用。
Front Cell Infect Microbiol. 2021 Aug 31;11:673724. doi: 10.3389/fcimb.2021.673724. eCollection 2021.
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