Wang Yilin, Wang Hongli
Department of Thyroid and Breast Surgery, Affiliated Hospital of Yangzhou University, Yangzhou, China; School of Medicine, Nantong University, Nantong, China.
Department of Thyroid and Breast Surgery, Affiliated Hospital of Yangzhou University, Yangzhou, China; School of Nursing, Yangzhou University, Yangzhou, China.
Sex Med. 2020 Jun;8(2):156-167. doi: 10.1016/j.esxm.2020.03.001. Epub 2020 Apr 13.
Hypothyroidism and subclinical hypothyroidism (SCH) are common metabolic diseases with severe psychological and physiological effects, which may be the risk factors of sexual dysfunction.
The purpose of this study is to explore the influence of hypothyroidism and SCH on female sexual function through systematic literature review.
Until February 2020, systematic searches were conducted on Pubmed, Web of Science, EMBASE, and Clinicalkey to obtain eligible studies to report the mean and standard deviation of Female Sexual Function Index (FSFI) in various fields in women with clinical hypothyroidism, SCH, and healthy controls. In accordance with the results of heterogeneity test, a random effect model or fixed effect model was selected to aggregate the scores of each field. The scores of female patients with hypothyroidism and healthy controls were compared using forest plot. Stata (version 15.1) uses meta-analysis.
Evaluation values of various fields of FSFI in clinical hypothyroidism, SCH, and healthy controls.
This study included 7 studies, including 88 women with clinical hypothyroidism, 337 women with SCH, and 2056 healthy controls. Compared with healthy controls, patients with hypothyroidism scored lower in all FSFI dimensions (desire, arousal, lubrication, orgasm, satisfaction, and pain), especially in lubrication. And, only arousal and orgasm decreased in patients with SCH. Hypothyroidism (odds ratio = 3.912, P = .002) rather than SCH (odds ratio = 1.036, P = .886) was a risk factor for female sexual dysfunction.
Hypothyroidism does impair female sexual function to varying degrees. SCH has little effect on female sexual function. It is essential to measure and evaluate the thyroid function of women with sexual dysfunction regularly, which can help clinicians improve sexual function and sexual quality of life. Wang Y and Wang H. Effects of Hypothyroidism and Subclinical Hypothyroidism on Sexual Function: A Meta-Analysis of Studies Using the Female Sexual Function Index. Sex Med 2020;8:156-167.
甲状腺功能减退症和亚临床甲状腺功能减退症（SCH）是常见的代谢性疾病，具有严重的心理和生理影响，可能是性功能障碍的危险因素。
本研究旨在通过系统的文献综述探讨甲状腺功能减退症和SCH对女性性功能的影响。
截至2020年2月，在PubMed、科学网、EMBASE和Clinicalkey上进行了系统检索，以获取符合条件的研究，报告临床甲状腺功能减退症、SCH女性及健康对照者在女性性功能指数（FSFI）各领域的均值和标准差。根据异质性检验结果，选择随机效应模型或固定效应模型汇总各领域得分。使用森林图比较甲状腺功能减退症女性患者和健康对照者的得分。采用Stata（版本15.1）进行荟萃分析。
临床甲状腺功能减退症、SCH及健康对照者FSFI各领域的评估值。
本研究纳入7项研究，包括88例临床甲状腺功能减退症女性、337例SCH女性和2056例健康对照者。与健康对照者相比，甲状腺功能减退症患者在FSFI所有维度（性欲、性唤起、润滑、性高潮、满意度和疼痛）的得分均较低，尤其是在润滑方面。而且，SCH患者仅性唤起和性高潮降低。甲状腺功能减退症（比值比=3.912，P=0.002）而非SCH（比值比=1.036，P=0.886）是女性性功能障碍的危险因素。
甲状腺功能减退症确实会不同程度地损害女性性功能。SCH对女性性功能影响较小。定期测量和评估性功能障碍女性的甲状腺功能至关重要，这有助于临床医生改善性功能和性生活质量。王Y和王H。甲状腺功能减退症和亚临床甲状腺功能减退症对性功能的影响：使用女性性功能指数的研究的荟萃分析。性医学2020；8：156-167。
