Ogawa Yusuke, Higuchi Takakazu, Koyamada Ryosuke, Arai Satoru, Okada Sadamu
Internal Medicine, St. Luke's International Hospital, Tokyo, Japan.
Division of Hematology, St. Luke's International Hospital, Tokyo, Japan.
J Hematol. 2017 Sep;6(2-3):68-71. doi: 10.14740/jh333w. Epub 2017 Jul 20.
A 64-year-old woman had a transformation from polycythemia vera to acute myeloid leukemia. While she was treated with azacitidine and prednisolone, a nodule at the left angle of the mouth developed, which was biopsied and diagnosed with hypertrophic herpes simplex virus type 1 (HSV-1) infection. The nodule resolved completely with aciclovir. While HSV type 2 virus occasionally forms mass or tumoral lesions in immunocompromised, especially acquired immunodeficiency syndrome, patients, it is extremely rare that HSV-1 infection leads to similar lesions. The hematological conditions and the therapies given may have contributed to the rare manifestation of HSV-1 infection.
一名64岁女性从真性红细胞增多症转变为急性髓系白血病。在她接受阿扎胞苷和泼尼松龙治疗期间，左侧口角出现一个结节，对其进行活检后诊断为肥厚性1型单纯疱疹病毒（HSV-1）感染。该结节使用阿昔洛韦后完全消退。虽然2型单纯疱疹病毒偶尔会在免疫功能低下的患者，尤其是获得性免疫缺陷综合征患者中形成肿块或肿瘤性病变，但HSV-1感染导致类似病变极为罕见。血液学状况及所给予的治疗可能促成了HSV-1感染的这种罕见表现。
