Karakousis Nikolaos D, Kanakas Charis A
2nd Department of Internal Medicine, Sismanogleio General Hospital, Athens, Greece.
Department of Radiology, Sismanogleio General Hospital, Athens, Greece.
J Frailty Sarcopenia Falls. 2017 Mar 1;2(1):6-8. eCollection 2017 Mar.
CREST syndrome, a subtype of scleroderma and Primary Biliary Cholangitis, is an autoimmune disease where the immune system is causing a progressive slow damage to the bile ducts. We report the case of a 67-year-old female patient presenting symptoms indicative of CREST syndrome. During her hospitalization in the internal medicine clinic and after the appropriate imaging and laboratory investigation the diagnosis of CREST syndrome was confirmed, and she was also diagnosed with PBC. This case adds up to a list of literature sources and several case reports which indicate the association of PBC and CREST syndrome, including the accompanied clinical symptoms and musculoskeletal manifestations of the latter.
CREST综合征是硬皮病和原发性胆汁性胆管炎的一种亚型，是一种自身免疫性疾病，免疫系统会对胆管造成渐进性的缓慢损害。我们报告了一例67岁女性患者，其出现了提示CREST综合征的症状。在内科门诊住院期间，经过适当的影像学和实验室检查后，确诊为CREST综合征，同时她也被诊断出患有原发性胆汁性胆管炎。该病例补充了一系列文献资料和多例病例报告，这些资料表明原发性胆汁性胆管炎与CREST综合征有关，包括后者伴随的临床症状和肌肉骨骼表现。
