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300μm 针深分数微针射频协同作用治疗衰老诱导的皮肤色素沉着过度。

Synergistic Effect of 300 μm Needle-Depth Fractional Microneedling Radiofrequency on the Treatment of Senescence-Induced Aging Hyperpigmentation of the Skin.

机构信息

Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul 03722, Korea.

Scar Laser and Plastic Surgery Center, Yonsei Cancer Hospital, Yonsei University College of Medicine, Seoul 03722, Korea.

出版信息

Int J Mol Sci. 2021 Jul 13;22(14):7480. doi: 10.3390/ijms22147480.

DOI:10.3390/ijms22147480
PMID:34299100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8305123/
Abstract

Aging-associated dermatological pigmentary diseases are associated with accumulation of senescence cells and the disruption of basement membrane due to chronic ultraviolet radiation (UVR) exposure. Our study is on the synergistic effect of the novel 300 μm needle-depth fractional microneedling radiofrequency (FMR) treatment and conventional Q-switched ND:YAG laser on aging-associated hyperpigmentation of the skin. The prospective controlled clinical trial of 25 Asian women revealed significantly higher improvements not only on wrinkles, but also on hyperpigmentation. Additional ex vivo study revealed significant reduction of pro-melanogenic markers as well as senescent keratinocytes, while increased expression of collagen type IV on the epidermal basement membrane, after additional FMR treatment on UV-irradiated human tissues. These results demonstrate that 300 μm needle-depth FMR might effectively remove senescent keratinocytes that secrete pro-melanogenic markers, and repair disrupted basement membrane, therefore preventing constant hyperpigmentation of the aged skin.

摘要

与衰老相关的皮肤色素疾病与衰老细胞的积累以及由于慢性紫外线辐射 (UVR) 暴露导致基底膜破裂有关。我们的研究是关于新型 300μm 针深分数微针射频 (FMR) 治疗与传统 Q 开关 ND：YAG 激光对皮肤与衰老相关的色素沉着的协同作用。对 25 名亚洲女性的前瞻性对照临床试验显示，不仅皱纹明显改善，而且色素沉着也明显改善。额外的离体研究显示，在对 UV 照射的人体组织进行额外的 FMR 治疗后，促黑素生成标志物和衰老角质形成细胞的表达显著减少，而表皮基底膜上的 IV 型胶原表达增加。这些结果表明，300μm 针深 FMR 可能有效地去除分泌促黑素生成标志物的衰老角质形成细胞，并修复破裂的基底膜，从而防止老年皮肤的持续色素沉着。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c7/8305123/c945a15dcb2f/ijms-22-07480-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c7/8305123/4fce513b9d10/ijms-22-07480-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37c7/8305123/3758cdb89994/ijms-22-07480-g003.jpg
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