Molloy A R, McMahon J N
Intensive Care Unit, Bristol Royal Infirmary, UK.
Intensive Care Med. 1988;15(1):60-2. doi: 10.1007/BF00255642.
Tracheopathia osteochondroplastica (TPO) is a rare, but increasingly recognised condition in which there is accumulation of calcium phosphate with benign submucous proliferation of cartilage and bone beneath the tracheal mucosa, often with squamous metaplasia of the mucosal columnar epithelium. This condition is usually asymptomatic, but may be slowly progressive, causing haemoptysis, dry cough and dyspnoea. We report a case of TPO in which there was rapid progression of tracheal stenosis such that the size of endotracheal tube that the upper airway would accept changed from 8.00 mm to 3.0 mm during a six-week period. This extreme reduction in airway calibre had not been detected on spirometry nine days prior to his final admission. This is the first report of such rapid progression of tracheal stenosis associated with TPO.
骨软骨化生型气管病（TPO）是一种罕见但越来越被认识到的疾病，其特征是磷酸钙积聚，伴有气管黏膜下软骨和骨的良性增生，常伴有黏膜柱状上皮的鳞状化生。这种疾病通常无症状，但可能缓慢进展，导致咯血、干咳和呼吸困难。我们报告一例TPO病例，该病例气管狭窄迅速进展，以至于在上气道能够接受的气管内导管尺寸在六周内从8.00毫米减小到3.0毫米。在他最后一次入院前九天的肺活量测定中未检测到气道口径如此极端的减小。这是首例与TPO相关的气管狭窄如此迅速进展的报告。
