THL Biobank, Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.
IARC, Lyon, France.
Biopreserv Biobank. 2020 Jun;18(3):155-164. doi: 10.1089/bio.2019.0129. Epub 2020 Apr 17.
The Minimum Information About BIobank data Sharing (MIABIS) was initiated in 2012. MIABIS aims to create a common biobank terminology to facilitate data sharing in biobanks and sample collections. The MIABIS Core terminology consists of three components describing biobanks, sample collections, and studies, in which information on samples and sample donors is provided at aggregated form. However, there is also a need to describe samples and sample donors at an individual level to allow more elaborate queries on available biobank samples and data. Therefore the MIABIS terminology has now been extended with components describing samples and sample donors at an individual level. The components were defined according to specific scope and use cases by a large group of experts, and through several cycles of reviews, according to the new MIABIS governance model of BBMRI-ERIC (Biobanking and Biomolecular Resources Research Infrastructure-European Research Infrastructure Consortium). The guiding principles applied in developing these components included the following terms: model should consider only samples of human origin, model should be applicable to all types of samples and all sample donors, and model should describe the current status of samples stored in a given biobank. A minimal set of standard attributes for defining samples and sample donors is presented here. We added an "event" component to describe attributes that are not directly describing samples or sample donors but are tightly related to them. To better utilize the generic data model, we suggest a procedure by which interoperability can be promoted, using specific MIABIS profiles. The MIABIS sample and donor component extensions and the new generic data model complement the existing MIABIS Core 2.0 components, and substantially increase the potential usability of this terminology for better describing biobank samples and sample donors. They also support the use of individual level data about samples and sample donors to obtain accurate and detailed biobank availability queries.
最小化生物库信息共享（MIABIS）术语标准于 2012 年启动。MIABIS 旨在创建一个通用的生物库术语，以促进生物库和样本库的数据共享。MIABIS 核心术语由三部分组成，分别描述生物库、样本库和研究，以聚合形式提供样本和样本提供者的信息。然而，也需要以个体水平描述样本和样本提供者，以便对可用的生物库样本和数据进行更详细的查询。因此，MIABIS 术语现在已经扩展到了描述个体水平的样本和样本提供者的组成部分。这些组成部分是由一大群专家根据特定的范围和用例定义的，并根据新的 MIABIS 治理模型（BBMRI-ERIC（生物库和生物分子资源研究基础设施-欧洲研究基础设施联盟））进行了几轮审查。在开发这些组成部分时应用的指导原则包括以下术语：模型应仅考虑人类来源的样本；模型应适用于所有类型的样本和所有样本提供者；模型应描述给定生物库中存储的样本的当前状态。这里提出了定义样本和样本提供者的最小标准属性集。我们添加了一个“事件”组件来描述那些不直接描述样本或样本提供者但与它们紧密相关的属性。为了更好地利用通用数据模型，我们建议采用一种使用特定 MIABIS 配置文件促进互操作性的程序。MIABIS 样本和供体组件扩展以及新的通用数据模型补充了现有的 MIABIS 核心 2.0 组件，极大地提高了该术语更好地描述生物库样本和样本提供者的潜在可用性。它们还支持使用个体水平的数据来获取关于样本和样本提供者的准确和详细的生物库可用性查询。
