Parveen Afsona, Chatterjee Arnab, Karak Prithviraj
Department of Bachelor in Medical Laboratory Technology, Durgapur Institute of Paramedical Science, West Bengal, India.
Department of Nutrition, Asansol Girls' College, West Bengal- 713304, India.
Adv Pharm Bull. 2025 May 31;15(2):232-247. doi: 10.34172/apb.025.44083. eCollection 2025 Jul.
Carbon-based nanoparticles possess distinctive chemical, physical, and biological characteristics that render them suitable for biomedical uses. This paper reviews recent advancements in carbon-based nanomaterial (CBs) synthesis methods, emphasizing the importance of careful modification for biomedical uses, particularly in the passivation of drugs and chemicals on their surfaces. This review article examines information from 2021-2024 regarding carbon-based nanoparticles and the biomedical uses of graphene, fullerene, carbon nanotubes, nano horns, nanodiamonds, quantum dots, and graphene oxide. Initially, a total of 5,612 relevant data points from various databases such as PubMed, ScienceDirect, and Web of Science were analyzed. After eliminating duplicates, nearly 3,905 data points were found to meet the inclusion criteria for this study, with the latest research indicating that 1,791 (45.8%) of these databases pertained to graphene. Carbon nanotubes accounted for approximately 928 (25.14%) databases, while graphene oxide represented around 837 (21.43%) databases, placing them in second and third positions, respectively. Nanohorns and fullerene were found in very minor quantities, specifically 34 (0.87%) and 06 (0.15%) in the database. CBNs, have the capacity to revolutionize biological medicine by improving regenerative treatments, personalized healthcare, and therapeutic outcomes. They are utilized in scaffolding, drug delivery, tissue engineering, bioimaging, and additional fields. Nonetheless, successful integration necessitates tackling scale and regulatory limitations.
碳基纳米颗粒具有独特的化学、物理和生物学特性,使其适用于生物医学用途。本文综述了碳基纳米材料(CBs)合成方法的最新进展,强调了为生物医学用途进行仔细修饰的重要性,特别是在其表面药物和化学物质的钝化方面。这篇综述文章研究了2021年至2024年期间关于碳基纳米颗粒以及石墨烯、富勒烯、碳纳米管、纳米角、纳米金刚石、量子点和氧化石墨烯的生物医学用途的信息。最初,对来自PubMed、ScienceDirect和Web of Science等各种数据库的总共5612个相关数据点进行了分析。在消除重复项后,发现近3905个数据点符合本研究的纳入标准,最新研究表明,这些数据库中有1791个(45.8%)与石墨烯有关。碳纳米管约占928个(25.14%)数据库,而氧化石墨烯约占837个(21.43%)数据库,分别位居第二和第三。纳米角和富勒烯的数量非常少,在数据库中分别为34个(0.87%)和6个(0.15%)。碳基纳米颗粒有能力通过改善再生治疗、个性化医疗和治疗效果来彻底改变生物医学。它们被用于支架、药物递送、组织工程、生物成像和其他领域。然而,要成功整合,必须解决规模和监管方面的限制。