儿童口腔伯基特淋巴瘤的临床病理分析：一项系统综述
Clinicopathological analysis of oral Burkitt's lymphoma in pediatric patients: A systematic review.
作者信息
Rodrigues-Fernandes Carla Isabelly, Pérez-de-Oliveira Maria Eduarda, Aristizabal Arboleda Lady Paola, Fonseca Felipe Paiva, Lopes Márcio Ajudarte, Vargas Pablo Agustin, Santos-Silva Alan Roger
机构信息
Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas, 13414-903, Piracicaba, São Paulo, Brazil.
Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas, 13414-903, Piracicaba, São Paulo, Brazil; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, Brazil; Department of Oral Biology and Oral Pathology, University of Pretoria, Pretoria, South Africa.
出版信息
Int J Pediatr Otorhinolaryngol. 2020 Jul;134:110033. doi: 10.1016/j.ijporl.2020.110033. Epub 2020 Apr 5.
The aim of this study was to integrate the available data regarding pediatric Burkitt's lymphoma (BL) of the oral cavity. A systematic review was conducted following PRISMA guidelines, through a specific search strategy. Twenty-nine publications were included in this study, resulting in a total of 144 cases. Oral BL was predominantly found in males (75.7%). The mandible was the most involved site (37.5%), and all cases clinically exhibited a swelling. Presence of EBV was observed in 33.3% of the cases, and 4 cases reported HIV-positive patients (33.3%). Chemotherapy was the leading treatment choice for oral BL (94.9%), and the overall 5-year survival was 54.3%. Regarding the quality assessment of the studies, most (19 studies; 65.5%) were classified as an overall moderate risk of bias. In conclusion, the clinicopathological characteristics of oral BL in the pediatric population comprise the sporadic and intermediate subtypes. Despite its aggressiveness, this malignancy presents a moderate overall survival.
本研究的目的是整合有关口腔小儿伯基特淋巴瘤（BL）的现有数据。按照PRISMA指南，通过特定的检索策略进行了系统评价。本研究纳入了29篇出版物，共计144例病例。口腔BL主要见于男性（75.7%）。下颌骨是最常受累的部位（37.5%），所有病例临床上均表现为肿胀。33.3%的病例检测到EBV存在，4例报告为HIV阳性患者（33.3%）。化疗是口腔BL的主要治疗选择（94.9%），总体5年生存率为54.3%。关于研究的质量评估，大多数（19项研究；65.5%）被归类为总体偏倚风险中等。总之，小儿口腔BL的临床病理特征包括散发性和中间亚型。尽管具有侵袭性，但这种恶性肿瘤的总体生存率中等。
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