耗竭朗格汉斯细胞可增强皮肤伤口愈合。
Depletion of langerin cells enhances cutaneous wound healing.
机构信息
Department of Pathology, University of Otago, Dunedin, New Zealand.
Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
出版信息
Immunology. 2020 Aug;160(4):366-381. doi: 10.1111/imm.13202. Epub 2020 May 15.
Langerin is a C-type lectin receptor that is expressed on Langerhans cells and langerin-positive dermal dendritic cells in the skin. Little is known about the function of langerin cells in wound healing. In this study, the effects of ablation of langerin cells on healing of a full-thickness excision wound were investigated using the langerin-DTR depletable mouse. Strikingly, depletion of langerin cells resulted in more rapid reduction in wound area. Accelerated wound healing in the langerin -cell-depleted group was characterized by enhanced neo-epidermis and granulation tissue formation, and increased cellular proliferation within the newly formed tissues. Accelerated healing in the absence of langerin cells was associated with increased levels of granulocyte-macrophage colony-stimulating factor, F4/80 cells and blood vessels within the granulation tissue. These data support an inhibitory role for langerin cells during wound healing. Therapies that suppress langerin cells or their function may therefore have utility in progressing the healing of wounds in humans.
朗格汉斯细胞是一种 C 型凝集素受体，存在于皮肤中的朗格汉斯细胞和朗格汉斯细胞阳性真皮树突状细胞上。关于朗格汉斯细胞在伤口愈合中的功能知之甚少。在这项研究中，使用朗格汉斯细胞-DTR 耗竭小鼠研究了朗格汉斯细胞耗竭对全层切除伤口愈合的影响。令人惊讶的是，朗格汉斯细胞耗竭导致伤口面积更快减少。朗格汉斯细胞耗竭组的伤口愈合加速表现为新表皮和肉芽组织形成增强，以及新形成组织内的细胞增殖增加。在没有朗格汉斯细胞的情况下，加速愈合与肉芽组织中粒细胞-巨噬细胞集落刺激因子、F4/80 细胞和血管水平的增加有关。这些数据支持朗格汉斯细胞在伤口愈合过程中起抑制作用。因此，抑制朗格汉斯细胞或其功能的疗法可能对促进人类伤口愈合具有实用价值。
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