Kim Hyun Kyun, Jeon Sung Hye, Ryu Ki Jin, Kim Tak, Park Hyuntae
Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.
J Menopausal Med. 2019 Dec;25(3):123-129. doi: 10.6118/jmm.19205.
This study aimed to compare the efficacy of tibolone and transdermal estrogen in treating menopausal symptoms in postmenopausal women with an intact uterus.
Overall, 26 women consumed tibolone orally and 31 women received transdermal estrogen gel mixed with progestogen. The menopause rating scale (MRS) was used to assess their menopausal symptoms at their first outpatient visit and 6 months later.
The transdermal estrogen group showed significant improvements in more items of the MRS questionnaire. There was a favorable change in body weight in the transdermal estrogen group compared with that in the tibolone group. Depressive mood, irritability, physical and mental exhaustion, sexual and bladder problems, and joint and muscular discomfort improved only in the transdermal estrogen group, whereas heart discomfort and vaginal dryness improved only in the tibolone group. Nevertheless, the intergroup differences in each item were insignificant after adjusting for body mass index and hypertension, which differed before treatment.
Both the therapeutic options improved menopausal symptoms within 6 months of use. However, transdermal estrogen appeared to be more effective in preventing weight gain in menopausal women than tibolone.
本研究旨在比较替勃龙与经皮雌激素治疗子宫完整的绝经后妇女绝经症状的疗效。
总体而言，26名女性口服替勃龙，31名女性接受经皮雌激素凝胶与孕激素混合制剂。采用绝经评定量表（MRS）在首次门诊就诊时及6个月后评估她们的绝经症状。
经皮雌激素组在MRS问卷的更多项目上有显著改善。与替勃龙组相比，经皮雌激素组体重有有利变化。抑郁情绪、易怒、身心疲惫、性和膀胱问题以及关节和肌肉不适仅在经皮雌激素组有所改善，而心脏不适和阴道干燥仅在替勃龙组有所改善。然而，在调整治疗前存在差异的体重指数和高血压后，各项目的组间差异不显著。
两种治疗方案在使用6个月内均改善了绝经症状。然而，经皮雌激素在预防绝经后妇女体重增加方面似乎比替勃龙更有效。
