对日本脑炎病毒甲基转移酶结构域中预测的蛋白酶切割进行分析。

Analysis of predicted proteasomal cleavages in the methyltransferase domain from JEV.

作者信息

Afaq Sarah, Malik Arshi, Akhtar Md Salman, Alwabli Afaf S, Alzahrani Dhafer A, Al-Solami Habeeb M, Alzahrani Othman, Alam Qamre, Kamal Mohammad Azhar, Abulfaraj Aala A, Tarique Mohammad

机构信息

Department of Clinical Biochemistry, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia.

Department of Basic Medical Sciences, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia.

出版信息

Bioinformation. 2020 Mar 31;16(3):223-228. doi: 10.6026/97320630016223. eCollection 2020.

The methyltransferase (MTase, a 265 amino acid residues long region at the N-terminal end of the viral nonfunctional supermolecule NS5 domain) is key for viral replication in Japanese Encephalitis Virus (JEV). Sequence to structure to functional information with adequate knowledge on MTase from JEV is currently limited. Therefore, it is of interest to document a report on the comprehensive analysis of predicted proteasomal cleavage data in the methyltransferase domain from JEV. This data is relevant in the design and development of vaccine and other therapeutic candidates for further consideration.