Tirukkolluru Chandrasekhar, Thakur Sophia
Department of Conservative and Endodontics, Bapuji Dental College and Hospital, Davangere, Karnataka, India.
Contemp Clin Dent. 2019 Apr-Jun;10(2):191-196. doi: 10.4103/ccd.ccd_195_18.
The antimicrobial efficacy of intracanal medicaments such as calcium hydroxide, propolis with moxifloxacin, and triple antibiotic paste (TAP) was assessed against spp. and in chronic apical periodontitis (AP) patients with Type II diabetes mellitus (DM).
This study design was a randomized clinical trial.
Forty-five Type II DM patients with single-rooted teeth diagnosed as AP were instrumented, randomly divided into three groups, and medicated with either TAP, propolis with moxifloxacin, or calcium hydroxide. Bacteriological samples obtained from the root canals after instrumentation (S1) in the first treatment session, and after medication (S2) in the second session 1 week later, were assessed for bacterial growth of and spp., by viable colony-forming unit counts.
Intragroup, intergroup, and pair-wise comparisons were done by Wilcoxon's signed ranked test, Kruskal-Wallis test, and Mann-Whitney test, respectively ( > 0.05).
The microbiological analysis showed a significant reduction in microbial count from (S1) to (S2) in all the study groups. However, intergroup comparisons revealed no significant difference in decrease of microbial load between all three groups at the end of 1 week.
Within the limitations of the study, it was concluded that antimicrobial efficacy of TAP, propolis with moxifloxacin, and calcium hydroxide were comparable.
评估根管内药物如氢氧化钙、含莫西沙星的蜂胶和三联抗生素糊剂（TAP）对II型糖尿病（DM）合并慢性根尖周炎（AP）患者根管内的 菌属和 菌属的抗菌效果。
本研究设计为随机临床试验。
45例诊断为AP的单根牙II型DM患者进行根管预备，随机分为三组，分别用TAP、含莫西沙星的蜂胶或氢氧化钙进行根管内封药。在首次治疗根管预备后（S1）以及1周后的第二次治疗封药后（S2），从根管中获取细菌样本，通过活菌计数评估 菌属和 菌属的细菌生长情况。
组内、组间和两两比较分别采用Wilcoxon符号秩和检验、Kruskal-Wallis检验和Mann-Whitney检验（P>0.05）。
微生物学分析显示，所有研究组从（S1）到（S2）的微生物计数均显著降低。然而，组间比较显示，在1周结束时，三组之间微生物负荷降低程度无显著差异。
在本研究的局限性范围内，得出结论：TAP、含莫西沙星的蜂胶和氢氧化钙的抗菌效果相当。
