中国聊城26例经人际传播的新型冠状病毒肺炎病例的流行病学及临床特征
Epidemiologic and Clinical Characteristics of 26 Cases of COVID-19 Arising from Patient-to-Patient Transmission in Liaocheng, China.
作者信息
Wang Lizhen, Duan Yueting, Zhang Wenming, Liang Juan, Xu Jianxiang, Zhang Yongqing, Wu Changgang, Xu Yangling, Li Hua
机构信息
Department of Tuberculosis, Liaocheng Infectious Disease Hospital, Liaocheng, Shandong, People's Republic of China.
Intensive Care Unit, Liaocheng Infectious Disease Hospital, Liaocheng, Shandong, People's Republic of China.
出版信息
Clin Epidemiol. 2020 Apr 9;12:387-391. doi: 10.2147/CLEP.S249903. eCollection 2020.
INTRODUCTION
Over 40,000 cases of coronavirus (CoV) disease 2019 (COVID-19) have been confirmed in China. The causative agent, 2019 novel CoV (2019-nCoV), has spread rapidly to more than 25 countries worldwide. Human-to-human transmission has accounted for most of the infections outside Wuhan. Most studies to date on COVID-19 have focused on disease etiology and the genomics of 2019-nCoV, with few reports on the epidemiologic and clinical characteristics of infected patients.
METHODS
We report early clinical features of 26 patients with confirmed COVID-19 who were admitted to Liaocheng Infectious Disease Hospital in Shandong Province.
RESULTS
The median age of the 26 patients with COVID-19 in this study was 42 years. The most common occupation was retail staff (16 patients, 61.54%), with 11 patients or their family members working at the same supermarket. Only 2 patients had visited Wuhan since December 2019; the other cases of 2019-nCoV infection arose from patient-to-patient transmission. Twelve patients had more than one sign or symptom; however, seven patients had no sign or symptom. The average time from symptom onset to admission was 4.5 days. CT revealed signs of bronchitis in 2 patients and unilateral and bilateral pneumonia in 9 and 15 patients, respectively. The patients received the following treatments: antiviral therapy (100%), Chinese medicine (76.92%), antibiotics (50%), gastric mucosal protection (19.23%), immunotherapy (7.69%), and glucocorticoids (3.85%). Most patients (25/26) required ≥1 treatment.
DISCUSSION
In contrast to previous reports, most patients (24/26) had not been in close contact with individuals from Wuhan. Additionally, 11 patients or their family members worked at the same supermarket, suggesting active viral transmission in a location frequented by a large number of people. Close monitoring is essential for preventing the large-scale spread of the virus in such places.
引言
中国已确诊4万多例新型冠状病毒2019感染的肺炎（COVID - 19）病例。病原体2019新型冠状病毒（2019 - nCoV）已迅速传播至全球25多个国家。武汉以外地区的大多数感染是由人传人所致。迄今为止，大多数关于COVID - 19的研究都集中在疾病病因和2019 - nCoV的基因组学上，关于感染患者的流行病学和临床特征的报道较少。
方法
我们报告了山东省聊城市传染病医院收治的26例确诊COVID - 19患者的早期临床特征。
结果
本研究中26例COVID - 19患者的中位年龄为42岁。最常见职业是零售员工（16例，61.54%），其中11例患者或其家庭成员在同一家超市工作。自2019年12月以来，只有2例患者去过武汉；其他2019 - nCoV感染病例是由人际传播引起的。12例患者有不止一种体征或症状；然而，7例患者没有体征或症状。从症状出现到入院的平均时间为4.5天。CT显示2例患者有支气管炎征象，9例和15例患者分别有单侧和双侧肺炎征象。患者接受了以下治疗：抗病毒治疗（100%）、中药（76.92%）、抗生素（50%）、胃黏膜保护（19.23%）、免疫治疗（7.69%）和糖皮质激素（3.85%）。大多数患者（25/26）需要≥1种治疗。
讨论
与之前的报道不同，大多数患者（24/26）未曾与来自武汉的人员密切接触。此外，11例患者或其家庭成员在同一家超市工作，这表明病毒在大量人员经常光顾的场所存在活跃传播。对此类场所进行密切监测对于预防病毒大规模传播至关重要。
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