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一名中年女性轴性骨骼原发性骨淋巴瘤表现为反复贫血。

Primary Bone Lymphoma in Axial Skeleton in a Middle-Aged Female Presented as Recurrent Anemia.

作者信息

Batia Tala, Yassin Mohamed A, Mudawi Deena S, Hamid Omnia A, Abdalhadi Ahmed M A

机构信息

Hamad Medical Corporation, Doha, Qatar.

出版信息

Case Rep Oncol. 2020 Mar 24;13(1):276-280. doi: 10.1159/000506362. eCollection 2020 Jan-Apr.

DOI:10.1159/000506362
PMID:32308590
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7154249/
Abstract

Primary bone lymphoma (PBL) is a peculiar extranodal presentation of non-Hodgkin's lymphoma. Primary bone diffuse large B-cell lymphoma (DLBCL) is the most common pathological type, comprising about 80% of PBL. The diagnosis of PBL depends on the combined clinical examination and imaging studies and is confirmed with immunohistochemical examination. Due to the rarity of this disease, more relative studies and case reports are needed to provide insight into this obscure lymphoproliferative malignancy. Here, we report one rare case of primary bone DLBCL involving the axial skeleton in a 37-year-old female.

摘要

原发性骨淋巴瘤(PBL)是非霍奇金淋巴瘤一种特殊的结外表现形式。原发性骨弥漫性大B细胞淋巴瘤(DLBCL)是最常见的病理类型,约占原发性骨淋巴瘤的80%。原发性骨淋巴瘤的诊断依赖于临床检查与影像学检查相结合,并通过免疫组化检查得以确诊。由于该疾病罕见,需要更多相关研究及病例报告来深入了解这种隐匿的淋巴增殖性恶性肿瘤。在此,我们报告一例罕见的原发性骨DLBCL病例,发生于一名37岁女性的中轴骨骼。

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本文引用的文献

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Primary Bone Lymphoma Exhibits a Favorable Prognosis and Distinct Gene Expression Signatures Resembling Diffuse Large B-Cell Lymphoma Derived From Centrocytes in the Germinal Center.原发性骨淋巴瘤预后良好,具有独特的基因表达特征,类似于生发中心起源的弥漫性大B细胞淋巴瘤。
Am J Surg Pathol. 2017 Oct;41(10):1309-1321. doi: 10.1097/PAS.0000000000000923.
2
Primary bone lymphoma with multifocal osteolytic lesions: a rare case report with review of literature.原发性骨淋巴瘤伴多灶性溶骨性病变:1例罕见病例报告并文献复习
Blood Res. 2015 Dec;50(4):256-60. doi: 10.5045/br.2015.50.4.256. Epub 2015 Dec 21.
3
Primary lymphoma of bone presenting as spindle cell neoplasm of the vertebral body: a case report and review of the literature.以椎体梭形细胞瘤形式表现的原发性骨淋巴瘤:一例报告并文献复习
Case Rep Hematol. 2015;2015:518307. doi: 10.1155/2015/518307. Epub 2015 Apr 23.
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Primary and secondary bone lymphomas.原发性和继发性骨淋巴瘤。
Cancer Treat Rev. 2015 Mar;41(3):235-46. doi: 10.1016/j.ctrv.2015.02.001. Epub 2015 Feb 7.
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Complementary roles of bone scintigraphy and MR imaging in the detection and long-term follow-up of primary non-Hodgkin's bone lymphoma in a child-case report.骨闪烁显像与磁共振成像在儿童原发性非霍奇金骨淋巴瘤检测及长期随访中的互补作用——病例报告
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