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毛壳球孢菌素的生物活性及未来展望

Bioactivities and Future Perspectives of Chaetoglobosins.

作者信息

Chen Jinhua, Zhang Wenzhou, Guo Qingfeng, Yu Weijiang, Zhang Yongna, He Baoxia

机构信息

Department of Pharmacy, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China.

Zhengzhou Key Laboratory of Medicinal Resources Research, Huanghe Science and Technology College, Zhengzhou 450063, China.

出版信息

Evid Based Complement Alternat Med. 2020 Mar 24;2020:8574084. doi: 10.1155/2020/8574084. eCollection 2020.

DOI:10.1155/2020/8574084
PMID:32308719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7132351/
Abstract

Chaetoglobosins belonging to cytochalasan alkaloids represent a large class of fungal secondary metabolites. To date, around 100 chaetoglobosins and their analogues have been isolated and identified over the years from a variety of fungi, mainly from the fungus . Studies have found that chaetoglobosins possess a broad range of biological activities, including antitumor, antifungal, phytotoxic, fibrinolytic, antibacterial, nematicidal, anti-inflammatory, and anti-HIV activities. This review will comprehensively summarize the biological activities and mechanisms of action of nature-derived chaetoglobosins.

摘要

属于细胞松弛素生物碱的毛球壳菌素是一大类真菌次生代谢产物。多年来，迄今已从多种真菌（主要是该真菌）中分离并鉴定出约100种毛球壳菌素及其类似物。研究发现，毛球壳菌素具有广泛的生物活性，包括抗肿瘤、抗真菌、植物毒性、纤维蛋白溶解、抗菌、杀线虫、抗炎和抗HIV活性。本文综述将全面总结天然来源的毛球壳菌素的生物活性及作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ee/7132351/4f5cd74bb75d/ECAM2020-8574084.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ee/7132351/0dd53a46ec3f/ECAM2020-8574084.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ee/7132351/375f184dc0e4/ECAM2020-8574084.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ee/7132351/4f5cd74bb75d/ECAM2020-8574084.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ee/7132351/0dd53a46ec3f/ECAM2020-8574084.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ee/7132351/375f184dc0e4/ECAM2020-8574084.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34ee/7132351/4f5cd74bb75d/ECAM2020-8574084.003.jpg

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