HPLC-DAD 引导的珊瑚共生真菌 C2F17 中多样的 Chaetoglobosins 分离
HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus C2F17.
机构信息
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
出版信息
Molecules. 2020 Mar 9;25(5):1237. doi: 10.3390/molecules25051237.
Cytochalasans have continuously aroused considerable attention among the chemistry and pharmacology communities due to their structural complexities and pharmacological significances. Sixteen structurally diverse chaetoglobosins, 10-(indol-3-yl)-[13]cytochalasans, including a new one, 6--methyl-chaetoglobosin Q (), were isolated from the coral-associated fungus C2F17. Their structures were accomplished by extensive spectroscopic analysis combined with single-crystal X-ray crystallography and ECD calculations. Meanwhile, the structures and absolute configurations of the previously reported compounds , , and were confirmed by single-crystal X-ray analysis for the first time. Chaetoglobosins E () and Fex () showed significant cytotoxicity against a panel of cancer cell lines, K562, A549, Huh7, H1975, MCF-7, U937, BGC823, HL60, Hela, and MOLT-4, with the IC values ranging from 1.4 μM to 9.2 μM.
由于其结构复杂性和药理学意义，细胞松弛素一直引起化学和药理学领域的极大关注。从珊瑚相关真菌 C2F17 中分离得到了十六种结构多样的 chaetoglobosins，10-(indol-3-yl)-[13]cytochalasans，包括一种新的 6--methyl-chaetoglobosin Q ()。通过广泛的光谱分析结合单晶 X 射线晶体学和 ECD 计算完成了它们的结构。同时，首次通过单晶 X 射线分析证实了先前报道的化合物 、 和 的结构和绝对构型。Chaetoglobosins E () 和 Fex () 对一组癌细胞系 K562、A549、Huh7、H1975、MCF-7、U937、BGC823、HL60、Hela 和 MOLT-4 表现出显著的细胞毒性，IC 值范围为 1.4 μM 至 9.2 μM。
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