沙查氏菌素 A 和 B：源自丹参的真菌 Chaetomium globosum D38 产生的细胞松弛素生物碱。

Salchaetoglobosins A and B: Cytochalasan alkaloids from Chaetomium globosum D38, a fungus derived from Salvia miltiorrhiza.

机构信息

Department of Chinese Medicine Authentication, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China; School of Life sciences, Inner Mongolia University, 235 West University Road, Hohhot 010021, China.

Department of Chinese Medicine Authentication, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.

出版信息

Fitoterapia. 2021 Jun;151:104874. doi: 10.1016/j.fitote.2021.104874. Epub 2021 Mar 3.

DOI:10.1016/j.fitote.2021.104874

PMID:33667565

Abstract

Chemical investigation on the solid rice culture of Chaetomium globosum D38, an endophytic fungus derived from Salvia miltiorrhiza, has afforded two new 19,20-seco-chaetoglobosins, salchaetoglobosins A (1) and B (2), along with three known analogues, chaetoglobosins E (3), Fex (4), and V (5). Their structures and absolute configurations were elucidated by a set of spectroscopy and single-crystal X-ray crystallography. Compounds 1-5 were evaluated for their cytotoxic activities against HCT-116 (colorectal carcinoma) and PC3 (prostate cancer) cells, as well as the NO production inhibitory effects in LPS-stimulated RAW264.7 cells.

摘要

从丹参内生真菌Chaetomium globosum D38 的固体大米培养物中进行的化学研究，得到了两种新的 19,20-裂殖环二萜，即 salchaetoglobosins A（1）和 B（2），以及三种已知的类似物，chaetoglobosins E（3）、Fex（4）和 V（5）。通过一系列光谱和单晶 X 射线晶体学解析了它们的结构和绝对构型。评估了化合物 1-5 对 HCT-116（结直肠癌）和 PC3（前列腺癌）细胞的细胞毒性活性，以及对 LPS 刺激的 RAW264.7 细胞中 NO 产生的抑制作用。