Shioya S, Haida M, Tsuji C, Ohta Y, Yamabayashi H, Fukuzaki M, Kimula Y
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.
Magn Reson Med. 1988 Dec;8(4):450-9. doi: 10.1002/mrm.1910080408.
Proton magnetic relaxation times, T1 and T2, were determined for rat lungs exposed to 80% oxygen for a duration of 2 weeks. The transverse magnetization decay curve of the lung tissue was multiexponential. A linear combination of two decay curves with different T2 values fits the multiexponential decay suggesting that there are at least two different components of tissue water in the lung. Remarkable prolongation of T1 and T2 was demonstrated as lung injuries progressed in the acute stage of pulmonary edema. Both 1/T1 and 1/T2 were significantly correlated with 1/water content of the lung tissue. In the repair stage, T1 and T2 were significantly shortened. Shortening coincided with the spontaneous resolution of pulmonary edema. Relaxation rates showed no significant correlation with 1/water content in this stage. These results indicate that the physical state of water in the tissue is affected not only by the water content but also by the derangement of macromolecules in pulmonary edema. T2 was more sensitive than T1 for detecting pulmonary damage.
测定了暴露于80%氧气环境中两周的大鼠肺组织的质子磁共振弛豫时间T1和T2。肺组织的横向磁化衰减曲线是多指数的。两条具有不同T2值的衰减曲线的线性组合拟合了多指数衰减，这表明肺组织中至少存在两种不同成分的组织水。在肺水肿急性期，随着肺损伤的进展，T1和T2显著延长。1/T1和1/T2均与肺组织的1/含水量显著相关。在修复期，T1和T2显著缩短。缩短与肺水肿的自然消退相一致。在此阶段，弛豫率与1/含水量无显著相关性。这些结果表明，组织中水的物理状态不仅受含水量的影响，还受肺水肿中大分子紊乱的影响。T2在检测肺损伤方面比T1更敏感。
