Shioya S, Tsuji C, Haida M, Fukuzaki M, Tanigaki T, Kurita D, Ohta Y, Yamabayashi H
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan.
Lung. 1996;174(4):235-41. doi: 10.1007/BF00173138.
Models of pulmonary edema have been used to study the nuclear magnetic resonance (NMR) characteristics of lung water. Several investigators have measured changes in the relaxation times in the permeability type of pulmonary edema, but relatively few have measured relaxation times in the hydrostatic type of pulmonary edema. In this study we determined the characteristics of NMR relaxation times T1, T2 (Hahn spin-echo decay) and water content in acute hydrostatic pulmonary edema induced by noradrenaline administration in rats. Changes in T1 and T2 showed a significant prolongation in hydrostatic pulmonary edema. T2 decay curves for peripheral lung tissues were multiexponential and fit two components [T2 fast (T2f) and T2 slow (T2s)]. With two-component T2 analysis, T2s showed greater prolongation than did T2f. The increase in T2s was significantly correlated with an increase in water content, but the increase in the T2f value was not correlated with water content or with a change in T2s. The T2s component, which likely reflected changes in interstitial water, was more closely related than the T2f component to an increase in water content in hydrostatic pulmonary edema. Results suggested that regional changes in hydrostatic pulmonary edema may be evaluated by multicomponent T2 analysis.
肺水肿模型已被用于研究肺水的核磁共振（NMR）特征。几位研究者测量了通透性型肺水肿中弛豫时间的变化，但测量静水压型肺水肿中弛豫时间的研究者相对较少。在本研究中，我们测定了在大鼠中通过给予去甲肾上腺素诱导的急性静水压性肺水肿中NMR弛豫时间T1、T2（哈恩自旋回波衰减）和含水量的特征。T1和T2的变化显示在静水压性肺水肿中有显著延长。外周肺组织的T2衰减曲线是多指数的，拟合为两个成分[T2快（T2f）和T2慢（T2s）]。通过双成分T2分析，T2s的延长比T2f更明显。T2s的增加与含水量的增加显著相关，但T2f值的增加与含水量或T2s的变化无关。T2s成分可能反映了间质水的变化，在静水压性肺水肿中，它比T2f成分与含水量的增加更密切相关。结果表明，静水压性肺水肿的区域变化可通过多成分T2分析进行评估。
