Bawah Ahmed Tijani, Tornyi Henry, Seini Mohammed Mustapha, Ngambire Lincoln Toamsoma, Yeboah Francis Agyemang
1Department of Medical Laboratory Sciences, University of Health and Allied Science, PMB 31, Ho, Ghana.
2Department of Molecular Medicine, Kwame Nkrumah University Science and Technology, Kumasi, Ghana.
Clin Hypertens. 2020 Apr 15;26:7. doi: 10.1186/s40885-020-00139-x. eCollection 2020.
Zonulin has been implicated in many metabolic disorders including hypertension and obesity. However, there is insufficient information about the involvement of zonulin in pregnancy induced hypertension (PIH) which comprises preeclampsia (PE) and gestational hypertension (GH). This study was therefore aimed at finding the level of this biochemical marker of regulation of tight junctions among women with PIH.
A total of 88 women with PIH and 60 age and body mass index (BMI) matched healthy pregnant women controls were enrolled. Blood pressure at 11-13 weeks and after 20 weeks of gestation, body mass index (BMI) in addition to serum Zonulin levels and lipid profile were compared between the groups. Student's t-test was used for comparisons of the mean between the two groups. Correlation analyses were performed using Pearson's correlation and binary logistic regression was used to evaluate the factors associated with PIH.
Zonulin level was significantly higher in the participants with PIH as compared to the normal pregnant controls 56.81 ± 7.72 ng/ml vs 40.4 ± 8.60 ng/ml < 0.0001 and had strong positive correlation with PIH (OR = 1.805; CI1.139-1.275; p < 0.0001). However, the association between first trimester lipids and PIH was weak.
The results showed a strong positive correlation between zonulin and PIH, thus changes in intestinal permeability occur in early stages of pregnancy and may be involved in the pathogenesis of PIH.
闭合蛋白与包括高血压和肥胖症在内的多种代谢紊乱有关。然而，关于闭合蛋白在包括先兆子痫（PE）和妊娠期高血压（GH）的妊娠高血压疾病（PIH）中的作用，目前信息不足。因此，本研究旨在确定这种紧密连接调节生化标志物在PIH女性中的水平。
共纳入88例PIH女性和60例年龄及体重指数（BMI）匹配的健康孕妇作为对照。比较两组在妊娠11 - 13周和20周后的血压、BMI、血清闭合蛋白水平及血脂谱。采用学生t检验比较两组均值。使用Pearson相关性进行相关分析，并采用二元逻辑回归评估与PIH相关的因素。
与正常妊娠对照组相比，PIH参与者的闭合蛋白水平显著更高（56.81±7.72 ng/ml对40.4±8.60 ng/ml，<0.0001），且与PIH呈强正相关（OR = 1.805；CI 1.139 - 1.275；p < 0.0001）。然而，孕早期血脂与PIH之间的关联较弱。
结果显示闭合蛋白与PIH之间存在强正相关，因此肠道通透性的变化发生在妊娠早期，可能参与了PIH的发病机制。
