Division of Obstetrics and Gynecology, Department of Clinical Sciences Lund, Lund University, 22185 Lund, Sweden.
Department of Obstetrics and Gynecology, Skåne University Hospital, 22242 Lund, Sweden.
Biomolecules. 2023 Feb 10;13(2):346. doi: 10.3390/biom13020346.
Preeclampsia is a severe pregnancy-related inflammatory disease without an effective treatment. The pathophysiology remains partly unknown. However, an increased inflammatory response and oxidative stress are part of the maternal systemic reaction. Recent data have suggested that dysbiosis of the gut microbiome plays a role in preeclampsia as well as other inflammatory diseases. However, dysbiosis in preeclampsia has not been studied in a Scandinavian population. Furthermore, although the fungal flora may also have anti-inflammatory properties, it has never been studied in preeclampsia. We included 25 preeclamptic and 29 healthy third-trimester women for the ITS and 16S sequencing of fungal and bacterial microbiota, respectively. Calprotectin was measured to assess systemic and intestinal inflammatory responses. The fungal diversity differed with BMI and gestational length, suggesting a link between fungi and the immune changes seen in pregnancy. An LEfSe analysis showed 18 significantly differentially abundant bacterial taxa in PE, including enriched and depleted and at the phylum level and depleted at the genus level, suggesting a role in the pathophysiology of PE.
子痫前期是一种严重的妊娠相关炎症性疾病，目前尚无有效的治疗方法。其病理生理学仍部分未知。然而，炎症反应和氧化应激增加是母体全身反应的一部分。最近的数据表明，肠道微生物组的失调与子痫前期以及其他炎症性疾病有关。然而，在斯堪的纳维亚人群中，尚未对子痫前期的微生物失调进行研究。此外，尽管真菌菌群也具有抗炎特性，但从未在子痫前期中进行过研究。我们分别纳入了 25 例子痫前期和 29 例健康的孕晚期妇女进行 ITS 和 16S 测序，以检测真菌和细菌微生物组。我们测量了钙卫蛋白以评估全身和肠道炎症反应。真菌多样性与 BMI 和妊娠时间有关，这表明真菌与妊娠期间的免疫变化之间存在联系。LEfSe 分析显示，PE 中有 18 种细菌分类群存在显著差异，包括丰富的 和减少的 和 在门水平，和减少的 在属水平，这表明它们可能与 PE 的病理生理学有关。
