Exercise & Memory Laboratory Department of Health, Exercise Science and Recreation Management, The University of Mississippi , University, MS, USA.
Digital Neuroscience Laboratory Department of Communication Sciences and Disorders, The University of Mississippi , University, MS, USA.
Phys Sportsmed. 2020 Nov;48(4):400-406. doi: 10.1080/00913847.2020.1758545. Epub 2020 Apr 29.
: To evaluate the influence of exercise on the body and genu of the corpus callosum (CC), which is a critical brain structure involved in facilitating interhemispheric communication. : Studies were identified using electronic databases, including PubMed, PsychInfo, Sports Discus and Google Scholar. The search terms, including their combinations, included exercise, physical activity, cardiorespiratory fitness, interhemispheric, and corpus callosum. To be eligible for inclusion in this review, studies had to be published in English; employ a cross-sectional, prospective or experimental design; include a measure of exercise as the independent variable; and the outcome variable had to include an integrity, volumetric or functional measure of the CC. Extraction parameters include study design, study population, exercise protocol, CC assessment, main findings regarding the relationship between exercise and the CC, and the evaluated or speculated mechanisms of this relationship. : 20 articles met the study inclusion criteria. Among these, 5 were conducted in animals and 15 were conducted in humans. Among the 5 animal studies, all provided suggestive evidence associating aerobic exercise with increased white matter integrity. Among the 15 human studies, 6 studies employed tract-based special statistics (TBSS), 4 utilized regions of interest (ROI) approach and 5 executed whole brain voxel wise analysis. Changes in the body was detected by 5 out of 6 TBSS studies and the genu by 3. Out of 4 ROI studies, three detected changes in the genu, but only one did in the body (out of 3 studies). One whole brain voxelwise study detected changes in the CC body of old adults and two found changes in the genu. : This review provides evidence to suggest that aerobic exercise, and in turn, enhanced cardiorespiratory fitness, are associated with structural and functional outcomes increasing CC integrity.
评估运动对胼胝体（CC）体部和膝部的影响，CC 是一个关键的大脑结构，参与促进大脑两半球间的交流。
使用电子数据库（包括 PubMed、PsychInfo、Sports Discus 和 Google Scholar）进行研究检索。搜索词及其组合包括运动、体育活动、心肺适能、大脑两半球间的、胼胝体。为了符合本综述的纳入标准，研究必须发表在英文期刊上；采用横断面、前瞻性或实验设计；将运动作为独立变量进行测量；并且结果变量必须包括 CC 的完整性、容积或功能测量。提取参数包括研究设计、研究人群、运动方案、CC 评估、关于运动与 CC 之间关系的主要发现，以及对这种关系的评估或推测机制。
20 篇文章符合研究纳入标准。其中，5 项在动物中进行，15 项在人体中进行。在 5 项动物研究中，所有研究都提供了提示性证据，表明有氧运动与增加白质完整性有关。在 15 项人体研究中，有 6 项研究采用了基于束的特殊统计（TBSS），4 项采用了感兴趣区域（ROI）方法，5 项采用了全脑体素分析。6 项 TBSS 研究中有 5 项检测到体部的变化，3 项检测到膝部的变化。4 项 ROI 研究中有 3 项检测到膝部的变化，而只有 1 项检测到体部的变化（在 3 项研究中）。一项全脑体素研究检测到老年人大脑 CC 体部的变化，两项研究发现 CC 膝部的变化。
本综述提供的证据表明，有氧运动，进而增强心肺适能，与结构和功能结果有关，增加 CC 的完整性。
