Rampally Vijay, Biri SaiRavi Kiran, Nair Indu K, Vadlakonda Arvind
Department of General Medicine, ESI Medical College and Hospital, Sanath Nagar, Hyderabad, Telangana, India.
Department of Biochemistry, Fakir Mohan Medical College and Hospital, Balasore, Odissa, India.
J Family Med Prim Care. 2020 Feb 28;9(2):1182-1186. doi: 10.4103/jfmpc.jfmpc_957_19. eCollection 2020 Feb.
Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the infiltration of fat in the liver cells. High levels of fat in the liver associated with increased risk of diseases like diabetes, high blood pressure and kidney disease, high cholesterol, metabolic syndrome.
To determine the association between NAFLD and carotid intima media thickness (CIMT) among nondiabetic individuals.
A total of 90 in-patients and outpatients (45 NAFL subjects and 45 patients with the normal liver as controls) with NAFL on abdomen ultrasound scan from Bangalore Baptist Hospital were included in our study. All the participants were subjected to a doppler study for carotid intima thickness and a blood sample (4 ml) was collected from all the subjects.
In this study, there is an elevated level of BMI, weight, dyslipidemia in NAFLD compared with controls. The present study suggests that cardiovascular risk factors such as increased carotid intima-media thickness occur more frequently among NAFLD patients compared to healthy individuals.
We can conclude that NAFL has a significant association with higher cardiovascular risk in terms of carotid intima-media thickness, dyslipidemia, and hypoalphalipidemia. Lifestyle changes include weight loss, dietary changes, reduction of sedentary habits and physical exercise are recommended in the NAFL disease subjects with higher BMI and weight.
非酒精性脂肪性肝病（NAFLD）是一种以肝细胞脂肪浸润为特征的疾病。肝脏中高水平的脂肪与糖尿病、高血压、肾脏疾病、高胆固醇、代谢综合征等疾病风险增加相关。
确定非糖尿病个体中NAFLD与颈动脉内膜中层厚度（CIMT）之间的关联。
我们的研究纳入了班加罗尔浸信会医院腹部超声扫描显示患有NAFLD的90名住院患者和门诊患者（45名NAFL受试者和45名肝脏正常的患者作为对照）。所有参与者均接受了颈动脉内膜厚度的多普勒研究，并从所有受试者中采集了4毫升血液样本。
在本研究中，与对照组相比，NAFLD患者的BMI、体重、血脂异常水平升高。本研究表明，与健康个体相比，NAFLD患者中诸如颈动脉内膜中层厚度增加等心血管危险因素更为常见。
我们可以得出结论，就颈动脉内膜中层厚度、血脂异常和低脂血症而言，NAFL与较高的心血管风险存在显著关联。建议BMI和体重较高的NAFLD患者改变生活方式，包括减肥、饮食改变、减少久坐习惯和进行体育锻炼。
