非酒精性脂肪性肝病与颈动脉内膜中层厚度的关系。
Association between nonalcoholic fatty liver disease and carotid intima-media thickness.
机构信息
Department of Internal Medicine, School of Medicine, Viet Nam National University Ho Chi Minh City, Vietnam.
Department of Internal Medicine, Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.
出版信息
Clin Ter. 2023 Jan-Feb;174(1):42-47. doi: 10.7417/CT.2023.5007.
BACKGROUND
Many non-invasive methods have been studied for assessing the severity of fatty liver disease and carotid intima-media thickness (CIMT). However, the correlation between hepatic steatosis and CIMT has not been fully studied, either globally or in Vietnam. This study investigated the association between nonalcoholic fatty liver disease (NAFLD) and CIMT.
METHODS
A cross-sectional study was performed on 125 patients at the Cardiology Department, the Emergency Interventional Cardiology Department, and the Internal Cardiology Clinic of Thong Nhat Hospital.
RESULTS
Among the 125 patients in our study population, NAFLD was diagnosed in 56%, and the mean CIMT was 0.89 ± 0.48 mm. Normal CIMT was measured in 21% of patients, whereas 79% had an elevated CIMT. The NAFLD rates were significantly different between patients with normal and increased CIMT, at 26.9% and 69.6%, respectively (p = 0.001).
CONCLUSIONS
Our study revealed a strong association between NAFLD and CIMT. NAFLD is currently considered a feature of metabolic syndrome, and an increase in the prevalence of NAFLD might result in an increase in the incidence of cardiovascular disease.
背景
许多非侵入性方法已被用于评估脂肪肝疾病和颈动脉内膜中层厚度（CIMT）的严重程度。然而，肝脂肪变性与 CIMT 之间的相关性尚未得到充分研究，无论是在全球范围内还是在越南。本研究探讨了非酒精性脂肪肝（NAFLD）与 CIMT 之间的关系。
方法
对通奈医院心脏病科、急诊介入心脏病科和内科心内科的 125 名患者进行了横断面研究。
结果
在我们的研究人群中，56%被诊断为非酒精性脂肪肝，平均 CIMT 为 0.89 ± 0.48mm。21%的患者 CIMT 正常，而 79%的患者 CIMT 升高。正常 CIMT 和升高 CIMT 的患者中，NAFLD 发生率分别为 26.9%和 69.6%，差异有统计学意义（p = 0.001）。
结论
本研究揭示了 NAFLD 与 CIMT 之间存在很强的相关性。NAFLD 目前被认为是代谢综合征的一个特征，NAFLD 患病率的增加可能导致心血管疾病的发病率增加。
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