Manhart Lisa E, Gaydos Charlotte A, Taylor Stephanie N, Lillis Rebecca A, Hook Edward W, Klausner Jeffrey D, Remillard Carmelle V, Love Melissa, McKinney Byron, Getman Damon K
Department of Epidemiology, University of Washington, Seattle, Washington, USA
Department of Global Health, University of Washington, Seattle, Washington, USA.
J Clin Microbiol. 2020 Jun 24;58(7). doi: 10.1128/JCM.00165-20.
Data from a large prospective multicenter clinical validation study of a nucleic acid amplification diagnostic test for were analyzed to describe the prevalence of infection, risk factors, and disease associations in female and male patients seeking care in diverse geographic regions of the United States. Among 1,737 female and 1,563 male participants, the overall prevalence of infection was 10.3% and was significantly higher in persons ages 15 to 24 years than in persons ages 35 to 39 years (for females, 19.8% versus 4.7% [odds ratio {OR} = 5.05; 95% confidence interval {CI} = 3.01 to 8.46]; for males, 16.5% versus 9.4% [OR = 1.91; 95% CI = 1.20 to 3.02]). The risk for infection was higher in black than in white participants (for females, 12.0% versus 6.8% [OR = 1.88; 95% CI = 1.30 to 2.72]; for males, 12.9% versus 6.9% [OR = 2.02; 95% CI = 1.38 to 2.96]) and higher in non-Hispanic than in Hispanic participants (for females, 11.2% versus 6.0% [OR = 1.97; 95% CI = 1.25 to 3.10]; for males, 11.6% versus 6.8% [OR = 1.80; 95% CI = 1.14 to 2.85]). Participants reporting urogenital symptoms had a significantly elevated risk of infection compared to that for asymptomatic individuals (for females, OR = 1.53 [95% CI = 1.09 to 2.14]; for males, OR = 1.42 [95% CI = 1.02 to 1.99]). Women diagnosed with vaginitis and cervicitis had a higher prevalence of infection than women without those diagnoses, although this was statistically significant only for vaginitis (for vaginitis, OR = 1.88 [95% CI = 1.37 to 2.58]; for cervicitis, OR = 1.42 [95% CI = 0.61 to 2.96]). A diagnosis of urethritis in men was also significantly associated with infection (OR = 2.97; 95% CI = 2.14 to 4.13). Few characteristics distinguished asymptomatic from symptomatic infections. These results from persons seeking care in the United States suggest that infection should be considered in young persons presenting with urogenital symptoms.
对一项核酸扩增诊断试验的大型前瞻性多中心临床验证研究数据进行了分析，以描述在美国不同地理区域寻求治疗的女性和男性患者中[病原体名称]感染的患病率、危险因素及疾病关联。在1737名女性和1563名男性参与者中，[病原体名称]感染的总体患病率为10.3%，15至24岁人群中的患病率显著高于35至39岁人群（女性中，19.8%对4.7%[优势比{OR}=5.05；95%置信区间{CI}=3.01至8.46]；男性中，16.5%对9.4%[OR=1.91；95%CI=1.20至3.02]）。黑人参与者感染[病原体名称]的风险高于白人参与者（女性中，12.0%对6.8%[OR=1.88；95%CI=1.30至2.72]；男性中，12.9%对6.9%[OR=2.02；95%CI=1.38至2.96]），非西班牙裔参与者的感染风险高于西班牙裔参与者（女性中，11.2%对6.0%[OR=1.97；95%CI=1.25至3.10]；男性中，11.6%对6.8%[OR=1.80；95%CI=1.14至2.85]）。与无症状个体相比，报告有泌尿生殖系统症状的参与者感染[病原体名称]的风险显著升高（女性中，OR=1.53[95%CI=1.09至2.14]；男性中，OR=1.42[95%CI=1.02至1.99]）。被诊断为阴道炎和宫颈炎的女性感染[病原体名称]的患病率高于未被诊断出这些疾病的女性，不过仅阴道炎的情况具有统计学意义（阴道炎中，OR=1.88[95%CI=1.37至2.58]；宫颈炎中，OR=1.42[95%CI=0.61至2.96]）。男性尿道炎的诊断也与[病原体名称]感染显著相关（OR=2.97；95%CI=2.14至4.13）。区分无症状和有症状[病原体名称]感染的特征很少。在美国寻求治疗的人群的这些结果表明，对于出现泌尿生殖系统症状的年轻人应考虑[病原体名称]感染。
