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纳米纤维羟丙基纤维素与β-环糊精聚氨酯复合垫的制备与评价

Preparation and Evaluation of Nanofibrous Hydroxypropyl Cellulose and β-Cyclodextrin Polyurethane Composite Mats.

作者信息

Gradinaru Luiza Madalina, Barbalata-Mandru Mihaela, Drobota Mioara, Aflori Magdalena, Spiridon Maria, Gradisteanu Pircalabioru Gratiela, Bleotu Coralia, Butnaru Maria, Vlad Stelian

机构信息

"P. Poni" Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania.

Sanimed International Impex S.R.L, 70F Bucuresti-Măgurele, 051434 Bucuresti, Romania.

出版信息

Nanomaterials (Basel). 2020 Apr 15;10(4):754. doi: 10.3390/nano10040754.

DOI:10.3390/nano10040754
PMID:32326486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7221721/
Abstract

A series of nanofibrous composite mats based on polyurethane urea siloxane (PUUS), hydroxypropyl cellulose (HPC) and β-cyclodextrin (β-CD) was prepared using electrospinning technique. PUUS was synthesized by two steps solution polymerization procedure from polytetramethylene ether glycol (PTMEG), dimethylol propionic acid (DMPA), 4,4'-diphenylmethane diisocyanate (MDI) and 1,3-bis-(3-aminopropyl) tetramethyldisiloxane (BATD) as chain extender. Then, the composites were prepared by blending PUUS with HPC or βCD in a ratio of 9:1 (w/w), in 15% dimethylformamide (DMF). The PUUS and PUUS based composite solutions were used for preparation of nanofibrous mats. In order to identify the potential applications, different techniques were used to evaluate the chemical structure (Fourier transform infrared-attenuated total reflectance spectroscopy-FTIR-ATR), morphological structure (Scanning electron microscopy-SEM and Atomic force microscopy-AFM), surface properties (contact angle, dynamic vapors sorption-DVS), mechanical characteristics (tensile tests), thermal (differential scanning calorimetry-DSC) and some preliminary tests for biocompatibility and microbial adhesion.

摘要

采用静电纺丝技术制备了一系列基于聚氨酯脲硅氧烷（PUUS）、羟丙基纤维素（HPC）和β-环糊精（β-CD）的纳米纤维复合垫。PUUS由聚四亚甲基醚二醇（PTMEG）、二羟甲基丙酸（DMPA）、4,4'-二苯基甲烷二异氰酸酯（MDI）和1,3-双（3-氨基丙基）四甲基二硅氧烷（BATD）作为扩链剂，通过两步溶液聚合程序合成。然后，将PUUS与HPC或β-CD按9:1（w/w）的比例在15%二甲基甲酰胺（DMF）中混合制备复合材料。将PUUS和基于PUUS的复合溶液用于制备纳米纤维垫。为了确定潜在应用，采用不同技术评估化学结构（傅里叶变换红外衰减全反射光谱-FTIR-ATR）、形态结构（扫描电子显微镜-SEM和原子力显微镜-AFM）、表面性质（接触角、动态蒸汽吸附-DVS）、机械特性（拉伸试验）、热性能（差示扫描量热法-DSC）以及一些生物相容性和微生物粘附的初步试验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/71eb8ceb33cd/nanomaterials-10-00754-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/ec989bf934a3/nanomaterials-10-00754-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/af7cebe08ee9/nanomaterials-10-00754-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/c3542457e3be/nanomaterials-10-00754-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/fabf44f563b1/nanomaterials-10-00754-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/71eb8ceb33cd/nanomaterials-10-00754-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/4f85a0045bc1/nanomaterials-10-00754-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/c9f5f7e5ca60/nanomaterials-10-00754-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/e5d17c0855a2/nanomaterials-10-00754-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/bad399423ae6/nanomaterials-10-00754-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/1c9d6628739a/nanomaterials-10-00754-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/3aa34d646464/nanomaterials-10-00754-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/dc9f349745fb/nanomaterials-10-00754-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/ec989bf934a3/nanomaterials-10-00754-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/af7cebe08ee9/nanomaterials-10-00754-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/c3542457e3be/nanomaterials-10-00754-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/fabf44f563b1/nanomaterials-10-00754-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8478/7221721/71eb8ceb33cd/nanomaterials-10-00754-g012.jpg

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