Mani Mohan Prasath, Jaganathan Saravana Kumar, Faudzi Ahmad Athif Mohd, Sunar Mohd Shahrizal
School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai 81310, Malaysia.
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City 71000, Vietnam.
Polymers (Basel). 2019 Apr 17;11(4):705. doi: 10.3390/polym11040705.
Cardiovascular application of nanomaterial's is of increasing demand and its usage is limited by its mechanical and blood compatible properties. In this work, an attempt is made to develop an electrospun novel nanocomposite loaded with basil oil and titanium dioxide (TiO) particles. The composite material displayed increase in hydrophobic and reduced fiber diameter compared to the pristine polymer. Fourier transform infrared spectroscopy results showed the interaction of the pristine polymer with the added substances. Thermal analysis showed the increased onset degradation, whereas the mechanical testing portrayed the increased tensile strength of the composites. Finally, the composite delayed the coagulation times and also rendered safe environment for red blood cells signifying its suitability to be used in contact with blood. Strikingly, the cellular toxicity of the developed composite was lower than the pristine polymer suggesting its compatible nature with the surrounding tissues. With these promising characteristics, developed material with enhanced physicochemical properties and blood compatibility can be successfully utilized for cardiac tissue applications.
纳米材料在心血管领域的应用需求日益增加，但其使用受到机械性能和血液相容性的限制。在这项工作中，人们尝试开发一种负载罗勒油和二氧化钛（TiO₂）颗粒的新型电纺纳米复合材料。与原始聚合物相比，该复合材料的疏水性增加，纤维直径减小。傅里叶变换红外光谱结果显示了原始聚合物与添加物质之间的相互作用。热分析表明起始降解温度升高，而力学测试表明复合材料的拉伸强度增加。最后，该复合材料延长了凝血时间，还为红细胞提供了安全的环境，表明其适合与血液接触使用。引人注目的是，所开发复合材料的细胞毒性低于原始聚合物，表明其与周围组织具有相容性。凭借这些有前景的特性，具有增强物理化学性质和血液相容性的开发材料可成功用于心脏组织应用。
