Lindskov R, Waersted A, Baadsgaard O, Søndergaard I
Dept. of Dermatology, Finsen Institute, Copenhagen, Denmark.
Allergy. 1988 Oct;43(7):519-22. doi: 10.1111/j.1398-9995.1988.tb01630.x.
To investigate whether the overall histamine turnover is increased in patients with atopic dermatitis, without respiratory disease, the urinary excretion of the main histamine metabolite 1.4-methyl-imidazoleacetic acid (MIAA) was examined in 23 patients and in 23 age- and sex-matched non-atopic controls. The patients excreted significantly more MIAA than the controls. One third of the patients however, showed MIAA excretion within or below normal range. The MIAA excretion was neither correlated to the severity of the eczema nor to the total serum IgE. It was concluded that histamine does not play a significant role in the pathophysiology of atopic dermatitis, and that the great variation in MIAA excretion, and hence the histamine turnover, reflected the spectrum of histamine releasability in the patients.
为了研究在无呼吸系统疾病的特应性皮炎患者中整体组胺周转率是否升高，对23例患者及23名年龄和性别匹配的非特应性对照者检测了主要组胺代谢产物1,4-甲基咪唑乙酸（MIAA）的尿排泄情况。患者排泄的MIAA显著多于对照者。然而，三分之一的患者MIAA排泄在正常范围内或低于正常范围。MIAA排泄与湿疹严重程度及总血清IgE均无相关性。得出的结论是，组胺在特应性皮炎的病理生理学中不发挥重要作用，且MIAA排泄的巨大差异以及由此产生的组胺周转率反映了患者体内组胺释放能力的范围。
