Holm-Bentzen M, Søndergaard I, Hald T
Br J Urol. 1987 Mar;59(3):230-3. doi: 10.1111/j.1464-410x.1987.tb04612.x.
Thirteen patients with interstitial cystitis (detrusor mastocytosis) and 12 other patients with painful bladder disease without mastocytosis collected 24-h urine specimens that were analysed for the major metabolite of histamine, 1,4-methyl-imidazole-acetic-acid (1,4-MIAA), by reversed phase ion-pair high performance liquid chromatography. The median urinary excretion of 1,4-MIAA was 3.34 mg/24 h (range 1.47-4.66) in the patients with detrusor mastocytosis and 1.75 mg/24 h (range 0.18-4.30) in the other patients with a painful bladder (P less than 0.01). It was concluded from this study that patients with a painful bladder and detrusor mastocytosis had a significantly elevated urinary excretion of 1,4-MIAA compared with other painful bladder patients without mastocytosis, whose urinary excretion of 1,4-MIAA was within the normal range (0.72-2.34 mg/24 h). We suggest that the urinary excretion of 1,4-MIAA might be useful in the diagnosis of interstitial cystitis.
13例间质性膀胱炎（逼尿肌肥大细胞增多症）患者和12例其他无肥大细胞增多症的膀胱疼痛疾病患者收集了24小时尿液标本，通过反相离子对高效液相色谱法分析组胺的主要代谢产物1,4-甲基咪唑乙酸（1,4-MIAA）。逼尿肌肥大细胞增多症患者的1,4-MIAA尿排泄中位数为3.34 mg/24小时（范围1.47 - 4.66），其他膀胱疼痛患者为1.75 mg/24小时（范围0.18 - 4.30）（P<0.01）。该研究得出结论，与其他无肥大细胞增多症的膀胱疼痛患者相比，伴有逼尿肌肥大细胞增多症的膀胱疼痛患者1,4-MIAA的尿排泄显著升高，后者1,4-MIAA的尿排泄在正常范围内（0.72 - 2.34 mg/24小时）。我们认为1,4-MIAA的尿排泄可能有助于间质性膀胱炎的诊断。
