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奥利司他对肥胖小鼠肠道微生物群的影响

Orlistat-Induced Gut Microbiota Modification in Obese Mice.

作者信息

Ke Jing, An Yaxin, Cao Bin, Lang Jianan, Wu Nannan, Zhao Dong

机构信息

Beijing Key Laboratory of Diabetes Research and Care, Center for Endocrine Metabolism and Immune Diseases, Lu He Hospital, Capital Medical University, Beijing, China.

出版信息

Evid Based Complement Alternat Med. 2020 Apr 8;2020:9818349. doi: 10.1155/2020/9818349. eCollection 2020.

DOI:10.1155/2020/9818349
PMID:32328145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7168719/
Abstract

INTRODUCTION

Accumulating evidence has indicated that alterations of gut microbiota have been involved in various metabolic diseases. Orlistat, a reversible inhibitor of pancreatic and gastric lipase, has beneficial effects on weight loss and metabolism. However, the effect of orlistat on the composition of gut microbiota remains unclear.

OBJECTIVE

We aimed to explore the effect of orlistat on gut microbiota in high-fat diet (HFD) fed C57BL/6J obese mice.

METHODS

C57BL/6J mice were randomly divided into three groups: control (NCD), HFD, and HFD + orlistat (ORL). Mice in the NCD group were fed chow diet, while the other groups were fed HFD for 6 months, and orlistat was added in the final 3 months in the HFD + ORL group. After sacrifice, body weight and metabolic parameters were assessed, and the gut microbial composition was analyzed by 16S rRNA gene sequencing.

RESULTS

Orlistat treatment exerted beneficial effects on body weight, plasma cholesterol, and glucose tolerance. Meanwhile, orlistat treatment modified the gut microbiota, presenting as reduced total microbial abundance and obvious upregulated bacteria. Moreover, the upregulated bacteria correlated with several metabolic pathways.

CONCLUSIONS

Orlistat may exert beneficial effects on body weight and glucose tolerance through modifying the composition of gut microbiota.

摘要

引言

越来越多的证据表明，肠道微生物群的改变与多种代谢性疾病有关。奥利司他是一种胰腺和胃脂肪酶的可逆抑制剂，对体重减轻和新陈代谢具有有益作用。然而，奥利司他对肠道微生物群组成的影响仍不清楚。

目的

我们旨在探讨奥利司他对高脂饮食（HFD）喂养的C57BL/6J肥胖小鼠肠道微生物群的影响。

方法

将C57BL/6J小鼠随机分为三组：对照组（正常饮食，NCD）、高脂饮食组（HFD）和高脂饮食+奥利司他组（HFD+ORL）。NCD组小鼠喂食普通饲料，而其他组喂食高脂饮食6个月，HFD+ORL组在最后3个月添加奥利司他。处死后，评估体重和代谢参数，并通过16S rRNA基因测序分析肠道微生物组成。

结果

奥利司他治疗对体重、血浆胆固醇和葡萄糖耐量产生有益影响。同时，奥利司他治疗改变了肠道微生物群，表现为总微生物丰度降低和明显上调的细菌。此外，上调的细菌与几种代谢途径相关。

结论

奥利司他可能通过改变肠道微生物群的组成对体重和葡萄糖耐量产生有益影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d06/7168719/bac79bc29301/ECAM2020-9818349.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d06/7168719/9e131f60901b/ECAM2020-9818349.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d06/7168719/fb42da938f09/ECAM2020-9818349.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d06/7168719/b98b0fd60153/ECAM2020-9818349.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d06/7168719/dea14adf655c/ECAM2020-9818349.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d06/7168719/eb7a54fad05a/ECAM2020-9818349.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d06/7168719/bac79bc29301/ECAM2020-9818349.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d06/7168719/9e131f60901b/ECAM2020-9818349.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d06/7168719/fb42da938f09/ECAM2020-9818349.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d06/7168719/b98b0fd60153/ECAM2020-9818349.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d06/7168719/dea14adf655c/ECAM2020-9818349.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d06/7168719/eb7a54fad05a/ECAM2020-9818349.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d06/7168719/bac79bc29301/ECAM2020-9818349.006.jpg

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