Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Department of Gastroenterology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
Biomed Pharmacother. 2020 Jul;127:110141. doi: 10.1016/j.biopha.2020.110141. Epub 2020 Apr 22.
Osteosarcoma is a bone tumor prevalent in children and young adults. LncRNAs are a family of non-protein-coding transcripts longer than 200 nucleotides. The tumor-related pathological functions of lncRNAs include proliferation, migration, and chemotherapy resistance, all of which have been widely acknowledged in research on osteosarcoma. In addition, compelling evidence suggests that lncRNAs could serve as diagnostic indicators, prognostic biomarkers, and targets for disease treatment. In this review, we systematically summarize how lncRNAs regulate tumorigenesis, invasion and therapeutic resistance. By deepening our knowledge of the relationship between lncRNAs and osteosarcoma, we hope to translate research findings into clinical applications as soon as possible.
骨肉瘤是一种常见于儿童和青少年的骨肿瘤。长链非编码 RNA（lncRNA）是一类长度大于 200 个核苷酸的非蛋白编码转录本。lncRNA 的肿瘤相关病理功能包括增殖、迁移和化疗耐药等，这些在骨肉瘤的研究中已得到广泛认可。此外，大量证据表明，lncRNA 可以作为诊断指标、预后生物标志物和疾病治疗靶点。在这篇综述中，我们系统地总结了 lncRNA 如何调节肿瘤发生、侵袭和治疗耐药性。通过加深我们对 lncRNA 与骨肉瘤之间关系的认识，我们希望尽快将研究成果转化为临床应用。
