Laboratory of Endocrinology and Metabolism, Department of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.
Curr Med Chem. 2021;28(9):1815-1828. doi: 10.2174/1567201816666190514101303.
Chronic consumption of alcohol has an adverse effect on the skeletal system, which may lead to osteoporosis, delayed fracture healing and osteonecrosis of the femoral head. Currently, the treatment is limited, therefore, there is an urgent need to determine the underline mechanism and develop a new treatment. It is well-known that normal bone remodeling relies on the balance between osteoclast-mediated bone resorption and - mediated bone formation. Various factors can destroy the balance, including the dysfunction of the immune system. In this review, we summarized the relevant research in the alcoholic osteopenia with a focus on the abnormal osteoimmunology signals. We provided a new theoretical basis for the prevention and treatment of the alcoholic bone.
We searched PubMed for publications from 1 January 1980 to 1 February 2020 to identify relevant and recent literature, summarizing evaluation and the prospect of alcoholic osteopenia. Detailed search terms were 'alcohol', 'alcoholic osteoporosis', 'alcoholic osteopenia' 'immune', 'osteoimmunology', 'bone remodeling', 'osteoporosis treatment' and 'osteoporosis therapy'.
A total of 135 papers are included in the review. About 60 papers described the mechanisms of alcohol involved in bone remodeling. Some papers were focused on the pathogenesis of alcohol on bone through osteoimmune mechanisms.
There is a complex network of signals between alcohol and bone remodeling and intercellular communication of osteoimmune may be a potential mechanism for alcoholic bone. Studying the osteoimmune mechanism is critical for drug development specific to the alcoholic bone disorder.
慢性饮酒对骨骼系统有不良影响，可能导致骨质疏松症、骨折愈合延迟和股骨头坏死。目前，治疗方法有限，因此，迫切需要确定潜在机制并开发新的治疗方法。众所周知，正常的骨骼重塑依赖于破骨细胞介导的骨吸收和 - 介导的骨形成之间的平衡。各种因素都可以破坏这种平衡，包括免疫系统的功能障碍。在这篇综述中，我们总结了酒精性骨质疏松症的相关研究，重点关注异常的骨免疫学信号。我们为酒精性骨病的预防和治疗提供了新的理论依据。
我们在 PubMed 上搜索了从 1980 年 1 月 1 日至 2020 年 2 月 1 日的出版物，以确定相关和最近的文献，总结了酒精性骨质疏松症的评估和前景。详细的搜索词是“酒精”、“酒精性骨质疏松症”、“酒精性骨质疏松症”、“免疫”、“骨免疫学”、“骨重塑”、“骨质疏松症治疗”和“骨质疏松症治疗”。
共有 135 篇论文纳入综述。约 60 篇论文描述了酒精参与骨重塑的机制。一些论文通过骨免疫机制集中研究了酒精对骨骼发病机制的影响。
酒精与骨重塑之间存在复杂的信号网络，骨免疫细胞间的通讯可能是酒精性骨病的潜在机制。研究骨免疫学机制对于开发针对酒精性骨病的特定药物至关重要。
