Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria; Division of Immunology and Pathophysiology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria.
Int Rev Cell Mol Biol. 2020;352:55-82. doi: 10.1016/bs.ircmb.2019.12.003. Epub 2020 Jan 13.
Unicellular organisms like yeast can undergo controlled demise in a manner that is partly reminiscent of mammalian cell death. This is true at the levels of both mechanistic and functional conservation. Yeast offers the combination of unparalleled genetic amenability and a comparatively simple biology to understand both the regulation and evolution of cell death. In this minireview, we address the capacity of the nucleus as a regulatory hub during yeast regulated cell death (RCD), which is becoming an increasingly central question in yeast RCD research. In particular, we explore and critically discuss the available data on stressors and signals that specifically impinge on the nucleus. Moreover, we also analyze the current knowledge on nuclear factors as well as on transcriptional control and epigenetic events that orchestrate yeast RCD. Altogether we conclude that the functional significance of the nucleus for yeast RCD in undisputable, but that further exploration beyond correlative work is necessary to disentangle the role of nuclear events in the regulatory network.
单细胞生物如酵母可以以一种部分类似于哺乳动物细胞死亡的方式进行受控死亡。这在机制和功能保守性方面都是如此。酵母提供了无与伦比的遗传可操作性和相对简单的生物学结合，以理解细胞死亡的调控和进化。在这篇简评中，我们探讨了细胞核作为酵母调控细胞死亡（RCD）的调节中心的能力，这在酵母 RCD 研究中越来越成为一个核心问题。特别是，我们探索和批判性地讨论了专门影响细胞核的应激源和信号的现有数据。此外，我们还分析了核因子以及转录控制和表观遗传事件的当前知识，这些事件协调了酵母 RCD。总的来说，我们得出结论，细胞核对酵母 RCD 的功能意义是毋庸置疑的，但需要进一步的探索超越相关工作，以理清核事件在调控网络中的作用。
