Trudel M, Nadon F, Séguin C, Payment P
Centre de recherche en virologie, Université du Québec, Ville de Laval, Canada.
Can J Microbiol. 1988 Dec;34(12):1351-4. doi: 10.1139/m88-238.
The purpose of this study was to evaluate experimentally the immunogenicity in rabbits of rubella subunits adsorbed to the adjuvant Quil A. The adsorbed viral proteins form structurally defined ImmunoStimulating COMplexes (ISCOMs). Rubella ISCOMs were tested for their capacity to induce neutralizing and hemagglutination-inhibiting antibodies, in comparison with a commercial live attenuated vaccine. Rubella ISCOMs were as efficient as the live vaccine in inducing neutralizing and hemagglutination inhibiting antibodies, suggesting the possibility of developing an ISCOMs subunit vaccine.
本研究的目的是通过实验评估吸附于佐剂Quil A的风疹亚单位在兔体内的免疫原性。吸附的病毒蛋白形成结构明确的免疫刺激复合物（ISCOMs）。将风疹ISCOMs与市售减毒活疫苗相比，测试其诱导中和抗体和血凝抑制抗体的能力。风疹ISCOMs在诱导中和抗体和血凝抑制抗体方面与活疫苗一样有效，这表明开发一种ISCOMs亚单位疫苗具有可能性。
