Lees A J, Blackburn N A, Campbell V L
Department of Neurology, University College Hospital, London, England.
Clin Neuropharmacol. 1988 Dec;11(6):512-9. doi: 10.1097/00002826-198812000-00004.
In a national survey conducted among 220 patients with Parkinson's disease (PD), 215 reported experiencing disabilities at night or on waking. The most common problems were inability to turn over or get out of bed and a frequent need to pass urine during the night. For the majority of patients, sleep was disrupted. Despite these difficulties, two-thirds of patients rated sleep quality as acceptable or good. The average duration of sleep was 6.5-7 h but approximately 8% of patients reported less than 5 h sleep per night. Hypnotic or sedative drugs were used by 29% of patients to help them sleep but only 6% took any antiparkinsonian medication during the night. Just over half the patients had told their doctor of nocturnal problems; prescription of hypnotic drugs or changes to antiparkinsonian therapy were the remedies most frequently tried. Problems at night are common in PD and, because of their debilitating effect on performance during the daytime, merit special attention.
在一项针对220名帕金森病（PD）患者开展的全国性调查中，215名患者报告在夜间或醒来时出现功能障碍。最常见的问题是无法翻身或起床以及夜间频繁需要排尿。对于大多数患者来说，睡眠受到干扰。尽管存在这些困难，但三分之二的患者将睡眠质量评为可接受或良好。平均睡眠时间为6.5 - 7小时，但约8%的患者报告每晚睡眠不足5小时。29%的患者使用催眠药或镇静药来帮助入睡，但只有6%的患者在夜间服用任何抗帕金森病药物。略超过一半的患者已将夜间问题告知医生；最常尝试的治疗方法是开具催眠药处方或调整抗帕金森病治疗方案。夜间问题在帕金森病中很常见，并且由于它们对白天功能的削弱作用，值得特别关注。
