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神经降压素及其受体在非胃肠癌中的作用：综述。

The role of Neurotensin and its receptors in non-gastrointestinal cancers: a review.

机构信息

Department of Colorectal Surgery, Chelsea and Westminster Hospital, NHS Foundation Trust, London, UK.

Department of Colorectal Surgery, Royal Marsden Hospital, London, UK.

出版信息

Cell Commun Signal. 2020 Apr 26;18(1):68. doi: 10.1186/s12964-020-00569-y.

DOI:10.1186/s12964-020-00569-y
PMID:32336282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7183616/
Abstract

BACKGROUND

Neurotensin, originally isolated in 1973 has both endocrine and neuromodulator activity and acts through its three main receptors. Their role in promoting tumour cell proliferation, migration, DNA synthesis has been studied in a wide range of cancers. Expression of Neurotensin and its receptors has also been correlated to prognosis and prediction to treatment.

MAIN BODY

The effects of NT are mediated through mitogen-activated protein kinases, epidermal growth factor receptors and phosphatidylinositol-3 kinases amongst others. This review is a comprehensive summary of the molecular pathways by which Neurotensin and its receptors act in cancer cells.

CONCLUSION

Identifying the role of Neurotensin in the underlying molecular mechanisms in various cancers can give way to developing new agnostic drugs and personalizing treatment according to the genomic structure of various cancers. Video abstract.

摘要

背景

神经降压素于 1973 年被首次分离，具有内分泌和神经调质双重活性，通过三种主要受体发挥作用。其在促进肿瘤细胞增殖、迁移和 DNA 合成方面的作用已在多种癌症中得到研究。神经降压素及其受体的表达也与预后和治疗预测相关。

主要内容

NT 的作用是通过丝裂原活化蛋白激酶、表皮生长因子受体和磷脂酰肌醇-3 激酶等介导的。这篇综述全面总结了神经降压素及其受体在癌细胞中作用的分子途径。

结论

确定神经降压素在各种癌症中潜在分子机制中的作用，可以为开发新的agnostic 药物和根据各种癌症的基因组结构进行个体化治疗铺平道路。视频摘要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/decd/7183616/63c9561b4920/12964_2020_569_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/decd/7183616/c1f030907892/12964_2020_569_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/decd/7183616/63c9561b4920/12964_2020_569_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/decd/7183616/c1f030907892/12964_2020_569_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/decd/7183616/63c9561b4920/12964_2020_569_Fig2_HTML.jpg

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