周围血管疾病间歇性跛行患者疾病特异性生活质量指标、身体机能与活动之间的关系。
Relationship Between Disease Specific Quality of Life Measures, Physical Performance, and Activity in People with Intermittent Claudication Caused by Peripheral Artery Disease.
机构信息
Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Australian Institute of Tropical Medicine, Townsville, Queensland, Australia; The Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Queensland, Australia.
Sport and Exercise Science, James Cook University, Townsville, Queensland, Australia.
出版信息
Eur J Vasc Endovasc Surg. 2020 Jun;59(6):957-964. doi: 10.1016/j.ejvs.2020.02.006. Epub 2020 Apr 23.
OBJECTIVE
The aims of this study were firstly to assess the correlation between disease specific measures of quality of life (QOL) and physical performance and activity, and secondly to identify demographic, clinical, functional, and physical activity measures independently associated with QOL in people with intermittent claudication.
METHODS
This was a cross sectional observational study of 198 people with intermittent claudication caused by peripheral artery disease who were recruited prospectively. QOL was assessed with the intermittent claudication questionnaire (ICQ) and the eight-theme peripheral artery disease quality of life questionnaire. Physical performance was assessed with the six minute walk test (6MWT) and short physical performance battery (SPPB), and an accelerometer was used to measure seven day step count. The associations between QOL scores and 6MWT distance, SPPB scores and seven day step count were examined using Spearman Rho's (ρ) correlation and multivariable linear regression.
RESULTS
ICQ scores were significantly correlated with 6MWT distance (ρ = 0.472, p < .001), all four SPPB scores (balance ρ = 0.207, p = .003; gait speed ρ = 0.303, p < .001; chair stand ρ = 0.167, p = .018; total ρ = 0.265, p < .001), and seven day step count (ρ = 0.254, p < .001). PADQOL social relationships and interactions (ρ = 0.343, p < .001) and symptoms and limitations in physical functioning (ρ = 0.355, p < .001) themes were correlated with 6MWT distance. The 6MWT distance was independently positively associated with ICQ and both PADQOL theme scores (ICQ: B 0.069, p < .001; PADQOL social relationships and interactions: B 0.077, p < .001; PADQOL symptoms and limitations in physical functioning: B 0.069, p < .001).
CONCLUSION
Longer 6MWT distance independently predicted better physical and social aspects of QOL in people with intermittent claudication supporting its value as an outcome measure.
目的
本研究的目的首先是评估特定疾病的生活质量（QOL）和身体表现与活动之间的相关性，其次是确定与间歇性跛行患者 QOL 相关的人口统计学、临床、功能和身体活动指标。
方法
这是一项前瞻性招募的 198 名外周动脉疾病所致间歇性跛行患者的横断面观察性研究。使用间歇性跛行问卷（ICQ）和 8 主题外周动脉疾病生活质量问卷评估 QOL。使用 6 分钟步行试验（6MWT）和简短身体表现电池（SPPB）评估身体表现，使用加速度计测量 7 天的步数。使用 Spearman Rho（ρ）相关和多变量线性回归检查 QOL 评分与 6MWT 距离、SPPB 评分和 7 天步数之间的关系。
结果
ICQ 评分与 6MWT 距离显著相关（ρ=0.472，p<0.001），所有四个 SPPB 评分（平衡ρ=0.207，p=0.003；步态速度ρ=0.303，p<0.001；椅子站立ρ=0.167，p=0.018；总ρ=0.265，p<0.001）和 7 天步数（ρ=0.254，p<0.001）。PADQOL 社会关系和相互作用（ρ=0.343，p<0.001）和症状与身体功能受限（ρ=0.355，p<0.001）主题与 6MWT 距离相关。6MWT 距离与 ICQ 和 PADQOL 主题评分独立呈正相关（ICQ：B0.069，p<0.001；PADQOL 社会关系和相互作用：B0.077，p<0.001；PADQOL 症状与身体功能受限：B0.069，p<0.001）。
结论
6MWT 距离越长，独立预测间歇性跛行患者的身体和社会方面的 QOL 越好，支持其作为结局测量的价值。
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