Key Laboratory of Tropical Disease Control of the Ministry of Education, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou510275, China.
Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou510275, China.
Parasitology. 2020 Aug;147(9):922-931. doi: 10.1017/S0031182020000645. Epub 2020 Apr 27.
Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense and caused devastating epidemics during the 20th century. Due to effective control programs implemented in the last two decades, the number of reported cases has fallen to a historically low level. Although fewer than 977 cases were reported in 2018 in endemic countries, HAT is still a public health problem in endemic regions until it is completely eliminated. In addition, almost 150 confirmed HAT cases were reported in non-endemic countries in the last three decades. The majority of non-endemic HAT cases were reported in Europe, USA and South Africa, due to historical alliances, economic links or geographic proximity to disease-endemic countries. Furthermore, with the implementation of the 'Belt and Road' project, sporadic imported HAT cases have been reported in China as a warning sign of tropical diseases prevention. In this paper, we explore and interpret the data on HAT incidence and find no positive correlation between the number of HAT cases from endemic and non-endemic countries. This data will provide useful information for better understanding the imported cases of HAT globally in the post-elimination phase.
人类非洲锥虫病（HAT）由布氏冈比亚锥虫和布氏罗得西亚锥虫引起，在 20 世纪曾引发毁灭性的流行。由于过去二十年中实施了有效的控制计划，报告的病例数量已降至历史最低水平。尽管 2018 年在流行国家报告的病例数少于 977 例，但在该疾病完全消除之前，它仍然是流行地区的公共卫生问题。此外，在过去三十年中，几乎有 150 例确诊的 HAT 病例在非流行国家报告。由于历史联盟、经济联系或与疾病流行国家的地理位置接近，大多数非流行 HAT 病例发生在欧洲、美国和南非。此外，随着“一带一路”项目的实施，中国也零星报告了输入性 HAT 病例，这是热带疾病预防的一个警示信号。本文旨在探讨和解释 HAT 发病率数据，并未发现来自流行和非流行国家的 HAT 病例数量之间存在正相关关系。这些数据将为更好地了解消除后阶段全球输入性 HAT 病例提供有用的信息。
